Protein detail

SRBS1

Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)

Entry name SRBS1	UniProt ID Q9BX66	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000095637

Entrez Gene Symbol

SORBS1

Gene Synonym

CAPFLJ12406KIAA1296ponsinSH3D5sh3p12

Gene Description

Sorbin and SH3 domain containing 1

Chromosome

Position

95311771-95561414

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M236 Pid delta np63 pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SORBS1	SRC	P12931	Y	536	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:19891780
SORBS1	ABL1	P00519	Y	536	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:19891780
SORBS1	CDK1	P06493	S	345	phosphorylation	KEA	KEA:17570479
SORBS1	GSK3B	P49841	S	345	phosphorylation	KEA	KEA:17570479
SORBS1	RPS6KA3	P51812	S	270	phosphorylation	KEA	KEA:17570479
SORBS1	RPS6KA3	P51812	S	345	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
adherens_junction	adherens_junction	Ramilowski_location	No	Yes	Yes	No	No
adherens_junction	adherens_junction	OmniPath	No	Yes	Yes	No	No
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes	No	Yes	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	Yes	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	No	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ABL1	P00519	SRBS1	Q9BX66	Yes	Yes	No	WangAdhesomeiPTMnetPhosphoPointSIGNORHPRDHINTBioGRIDSPIKE_LCSPIKE	Adhesome:19891780 HINT:19891780 SIGNOR:19891780 HPRD:11374898 SPIKE:19891780 HINT:11374898 SPIKE_LC:17145710 Adhesome:18768933 SPIKE_LC:20841568 SPIKE_LC:19891780 SPIKE:20841568 Adhesome:11374898 BioGRID:11374898
SRBS1	Q9BX66	CBL	P22681	Yes	Yes	No	HPRDWangSIGNORAdhesome	Adhesome:12765336 Adhesome:9447983 HPRD:11001060 Adhesome:12504111 SIGNOR:11001060 Adhesome:15128873 Adhesome:17548467

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACTA1 ACTB ACTL6A DMAP1 EPC2 KAT5 MEAF6 MORF4L1 MORF4L2 MRGBP NRAP SORBS1 TRRAP VPS72 YEATS4	O95619 O96019 P60709 P68133 Q15014 Q15906 Q52LR7 Q86VF7 Q92993 Q9BX66 Q9HAF1 Q9NPF5 Q9NV56 Q9UBU8 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4048
ACTA1 ACTL6A DMAP1 EPC1 EPC2 ING3 KAT5 MEAF6 MORF4L1 MORF4L2 MRGBP SORBS1 TRRAP VPS72 YEATS4	O95619 O96019 P68133 Q15014 Q15906 Q52LR7 Q92993 Q9BX66 Q9H2F5 Q9HAF1 Q9NPF5 Q9NV56 Q9NXR8 Q9UBU8 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5844
SORBS1 VCL	P18206 Q9BX66	1:1	PDB	PDB:4ln2PDB:4lnp
PXN SORBS1	P49023 Q9BX66	1:1	PDB	PDB:2o9v

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	6	38037300 40689422 38871114 34265469 38576002 39996590

Sequence, Structure & Domains

Sequences

Length

1,292

Mass

142,513

Sequence

MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMDLTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL

Alternative Products

Event=Alternative splicing; Named isoforms=12; Name=1; IsoId=Q9BX66-1; Sequence=Displayed; Name=2; IsoId=Q9BX66-2; Sequence=VSP_050902, VSP_050910; Name=3; IsoId=Q9BX66-3; Sequence=VSP_050898, VSP_050900, VSP_050906, VSP_050912, VSP_050913; Name=4; IsoId=Q9BX66-4; Sequence=VSP_050895, VSP_050896, VSP_050899, VSP_050900, VSP_050903, VSP_050907, VSP_050911; Name=5; IsoId=Q9BX66-5; Sequence=VSP_050896, VSP_050901, VSP_050911; Name=6; IsoId=Q9BX66-6; Sequence=VSP_050896, VSP_050899, VSP_050905, VSP_050911; Name=7; IsoId=Q9BX66-7; Sequence=VSP_050895, VSP_050896, VSP_050900, VSP_050903, VSP_050908, VSP_050909; Name=8; IsoId=Q9BX66-8; Sequence=VSP_050895, VSP_050899, VSP_050900, VSP_050904, VSP_050911; Name=9; IsoId=Q9BX66-9; Sequence=VSP_050899, VSP_050900, VSP_050903, VSP_050911; Name=10; IsoId=Q9BX66-10; Sequence=VSP_050895, VSP_050900, VSP_050903, VSP_050907, VSP_050911; Name=11; IsoId=Q9BX66-11; Sequence=VSP_050900, VSP_039210; Name=12; IsoId=Q9BX66-12; Sequence=VSP_050895, VSP_050899, VSP_041193, VSP_050900, VSP_050904, VSP_041194, VSP_050911

Alternative Sequence

26..57; Missing (in isoform 4, isoform 7, isoform 8, isoform 10 and isoform 12); 101..109; Missing (in isoform 4, isoform 5, isoform 6 and isoform 7); 147..215; Missing (in isoform 3); 148..270; Missing (in isoform 4, isoform 6, isoform 8, isoform 9 and isoform 12); 319..328; Missing (in isoform 12); 408..453; Missing (in isoform 3, isoform 4, isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12); 431..451; Missing (in isoform 5); 434..453; DNPYTPTYQFPASTPSPKSE -> TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA (in isoform 2); 552..635; Missing (in isoform 4, isoform 7, isoform 9 and isoform 10); 580..635; Missing (in isoform 6); 580..601; Missing (in isoform 8 and isoform 12); 602..635; Missing (in isoform 3); 709; K -> KVDRKGGNAHMISSSSVHSRTFNTSNALGPVCKHKKPLSAAKACISEILPSKFKPRLSAPSALLQEQKSILLPSEKAQSCENLCVSGSLNDSKRGLPLQVGGSIENLLMRSRRDYDSKSSSTMSLQEYSTSGRRPCPLSRKAGMQFTMLYRDMHQINRSGLFLGSISSSSSVRDLASHFEKSSLALSRGELGPSQEGSEHIPKHTVSSRITAFEQLIQRSRSMPSLDLSGRLSKSPTPVLSRGSLTSARSAESLLESTKLHPKEMDGMNSSGVYASPTCSNMAHHALSFRGLVPSEPLSTCSDDVDRCSNISTDSREGSGGSVHGDFPKHRLNKCKGTCPASYTRFTTIRKHEQQQTSRQPEWRLDARGDKSTLLRNIYLMSPLPFRLKKPLHHHPRQPSPGDSSGLLVGQKPDLPSQPHQDQPPSGGKPVVPTRLSSRHTMARLSRSSEPSQERPTALEDYPRAINNGNSVPYSDHSLDRNNNPQSELAPSRG (in isoform 12); 738..793; Missing (in isoform 4 and isoform 10); 795..799; MRPAR -> KYDWA (in isoform 7); 800..1292; Missing (in isoform 7); 955..1212; Missing (in isoform 4, isoform 5, isoform 6, isoform 8, isoform 9, isoform 10 and isoform 12); 955..1117; Missing (in isoform 2); 956..975; FSSHSKLITPAPSSLPHSRR -> LSHHSLRAGPDLTESEKSYV (in isoform 3); 976..1213; Missing (in isoform 3); 1213; Q -> QLSHHSLRAGPDLTESEKSYV (in isoform 11)

3D Structural Models

Turn

910..912; 1274..1276

Helix

844..846; 920..922

Beta Strand

796..802; 808..811; 819..825; 827..835; 838..843; 847..849; 863..865; 870..874; 882..885; 893..899; 901..908; 915..919; 923..927; 1230..1233; 1235..1240; 1257..1263; 1267..1273; 1279..1283; 1286..1289

3D Structure

NMR spectroscopy (5); X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

74..89; Low complexity; 93..102; Basic and acidic residues; 114..128; Polar residues; 240..252; Pro residues; 266..275; Polar residues; 354..365; Basic and acidic residues; 437..450; Polar residues; 510..534; Basic and acidic residues; 944..954; Low complexity; 955..971; Polar residues; 1106..1117; Polar residues; 1119..1136; Basic and acidic residues; 1162..1172; Polar residues; 1192..1203; Basic and acidic residues; 1211..1230; Polar residues

Domain (FT)

366..469; SoHo; 793..852; SH3 1; 867..928; SH3 2; 1231..1292; SH3 3

Region

1..29; Disordered; 73..158; Disordered; 214..275; Disordered; 318..381; Disordered; 405..534; Disordered; 628..650; Disordered; 692..716; Disordered; 944..976; Disordered; 1041..1064; Disordered; 1106..1150; Disordered; 1162..1230; Disordered

Clinical Relevance

Antibody

HPA027559 CAB032850 HPA043084

Interaction Protein

ENSG00000097007ENSG00000165458

Interaction Count

Interaction Dataset

intact_biogrid