Protein detail
SHAN3
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Protein symbol SHAN3 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Human disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Protein Class
Human disease related genesPredicted intracellular proteins
Protein Function
- Human disease related genes:Other congenital disorders:Chromosomal abnormalities
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1650prosap2PSAP2SPANK-2
Gene Description
SH3 and multiple ankyrin repeat domains 3
Chromosome
22
Position
50674415-50733212
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificlungCell SpecificAlveolar cells type 2
Function & Pathway
Protein Function
- Human disease related genes:Other congenital disorders:Chromosomal abnormalities
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DLGP3 | O95886 | SHAN3 | Q9BYB0 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| MK01 | P28482 | SHAN3 | Q9BYB0 | Yes | No | Yes | SIGNOR | SIGNOR:30696942 |
| SHAN3 | Q9BYB0 | GRIA2 | P42262 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| SHAN3 | Q9BYB0 | GRIA4 | P48058 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| SHAN3 | Q9BYB0 | GRIA3 | P42263 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| DLGP2 | Q9P1A6 | SHAN3 | Q9BYB0 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| CTTB2 | Q8WZ74 | SHAN3 | Q9BYB0 | Yes | Yes | No | SIGNOR | SIGNOR:35562389 |
| DLGP1 | O14490 | SHAN3 | Q9BYB0 | Yes | Yes | No | HINTSIGNOR | SIGNOR:28179641HINT:20573181 |
| SHAN3 | Q9BYB0 | GRIA1 | P42261 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
| SHAN3 | Q9BYB0 | ACTN1 | P12814 | Yes | Yes | No | SIGNOR | SIGNOR:28179641 |
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Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HTTL3MBTL3PRMT2SHANK3USP51 | P42858P55345Q70EK9Q96JM7Q9BYB0 | 0:0:0:0:0 | hu.MAP | |||
| HTTPRMT2SHANK3USP51 | P42858P55345Q70EK9Q9BYB0 | 0:0:0:0 | hu.MAP | |||
| L3MBTL3PRMT2SAMD1SAMD13SHANK3USP51 | P55345Q5VXD3Q6SPF0Q70EK9Q96JM7Q9BYB0 | 0:0:0:0:0:0 | hu.MAP2 | |||
| L3MBTL3PRMT2SHANK3USP51 | P55345Q70EK9Q96JM7Q9BYB0 | 0:0:0:0 | hu.MAP | |||
| RAP1BSHANK3 | P61224Q9BYB0 | 2:2 | PDB | PDB:7c7iPDB:7c7j |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 37427430 |
Sequence, Structure & Domains
Sequences
Length
1,806
Mass
191,338
Sequence
MQLSRAAAAAAAAPAEPPEPLSPAPAPAPAPPGPLPRSAADGAPAGGKGGPGRRAESPGAPFPGASGPGPGPGAGMDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISPSGPGGPGPAPGPGPAPPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERALRQLDGS
Alternative Products
Event=Alternative promoter usage; Named isoforms=2; Comment=Additional isoforms seem to exist. These isoforms may be the product of multiple intragenic promoter and/or alternative splicing.; Name=1; Synonyms=A; IsoId=Q9BYB0-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9BYB0-3; Sequence=VSP_053605
Alternative Sequence
76..194; Missing (in isoform 2)
3D Structural Models
Turn
118..120
Helix
91..93; 107..117; 125..127; 149..151; 597..599
Beta Strand
84..90; 95..101; 128..132; 145..148; 156..160; 162..167; 551..553; 561..564; 572..578; 580..588; 591..596; 600..602
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1..14; Low complexity; 15..35; Pro residues; 66..78; Gly residues; 482..491; Basic and acidic residues; 514..536; Pro residues; 888..920; Pro residues; 981..990; Pro residues; 1068..1088; Gly residues; 1190..1199; Low complexity; 1248..1268; Basic and acidic residues; 1326..1336; Pro residues; 1435..1445; Basic and acidic residues; 1446..1467; Low complexity; 1519..1535; Low complexity; 1570..1580; Polar residues; 1702..1712; Low complexity; 1713..1732; Pro residues
Repeat
223..253; ANK 1; 257..286; ANK 2; 290..320; ANK 3; 324..353; ANK 4; 357..386; ANK 5; 390..420; ANK 6
Motif
1485..1491; SH3-binding
Coiled Coil
1569..1589
Domain (CC)
In isoform 1, the N-terminal region preceding the ANK repeats interacts with the 6 ANK repeats in an intramolecular manner, thereby restricting access to ligands, such as SHARPIN and SPTAN1..
Domain (FT)
546..605; SH3; 646..740; PDZ; 1743..1806; SAM
Region
1..80; Disordered; 76..150; Intramolecular interaction with the ANK repeats; 482..542; Disordered; 740..764; Disordered; 753..760; Required for interaction with ABI1; 835..928; Disordered; 946..1096; Disordered; 1190..1535; Disordered; 1550..1600; Disordered; 1621..1659; Disordered; 1702..1739; Disordered
Clinical Relevance
Antibody