Protein detail

SHAN3

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)

Protein symbol SHAN3	UniProt ID Q9BYB0	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Human disease related genesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)

Protein Class

Human disease related genesPredicted intracellular proteins

Protein Function

Human disease related genes:Other congenital disorders:Chromosomal abnormalities
Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins

Ensembl

ENSG00000251322

Entrez Gene Symbol

SHANK3

Gene Synonym

KIAA1650prosap2PSAP2SPANK-2

Gene Description

SH3 and multiple ankyrin repeat domains 3

Chromosome

Position

50674415-50733212

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificlungCell SpecificAlveolar cells type 2

Function & Pathway

Protein Function

Human disease related genes:Other congenital disorders:Chromosomal abnormalities
Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04724 Glutamatergic synapse

Mediation Categories

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

12 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DLGP5	Q15398	SHAN3	Q9BYB0	Yes	Yes	No	SIGNOR	SIGNOR:28179641
DLGP4	Q9Y2H0	SHAN3	Q9BYB0	Yes	Yes	No	SIGNOR	SIGNOR:28179641

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Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
HTT L3MBTL3 PRMT2 SHANK3 USP51	P42858 P55345 Q70EK9 Q96JM7 Q9BYB0	0:0:0:0:0	hu.MAP
HTT PRMT2 SHANK3 USP51	P42858 P55345 Q70EK9 Q9BYB0	0:0:0:0	hu.MAP
L3MBTL3 PRMT2 SAMD1 SAMD13 SHANK3 USP51	P55345 Q5VXD3 Q6SPF0 Q70EK9 Q96JM7 Q9BYB0	0:0:0:0:0:0	hu.MAP2
L3MBTL3 PRMT2 SHANK3 USP51	P55345 Q70EK9 Q96JM7 Q9BYB0	0:0:0:0	hu.MAP
RAP1B SHANK3	P61224 Q9BYB0	2:2	PDB	PDB:7c7iPDB:7c7j

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	1	37427430

Sequence, Structure & Domains

Sequences

Length

1,806

Mass

191,338

Sequence

MQLSRAAAAAAAAPAEPPEPLSPAPAPAPAPPGPLPRSAADGAPAGGKGGPGRRAESPGAPFPGASGPGPGPGAGMDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTAVHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGITDENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRGANRDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGEAQPAASPGPSLRSLPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISPSGPGGPGPAPGPGPAPPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQHDTRPETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAVLQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPEEDGARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYEPGAALGPLPYPERQKRARSMIILQDSAPESGDAPRPPPAATPPERPKRRPRPPGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPGGGSFAREPSPTHRGPRPGGLDYGAGDGPGLAFGGPGPAKDRRLEERRRSTVFLSVGAIEGSAPGADLPSLQPSRSIDERLLGTGPTAGRDLLLPSPVSALKPLVSGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQAPSRSPTPVHSPDADRPGPLFVDVQARDPERGSLASPAFSPRSPAWIPVPARREAEKVPREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPSRLGGAEEERPGTPELAPAPMQSAAVAEPLPSPRAQPPGGTPADAGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARLFSSLGELSSISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPASGPGPGAPGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHRMNIERALRQLDGS

Alternative Products

Event=Alternative promoter usage; Named isoforms=2; Comment=Additional isoforms seem to exist. These isoforms may be the product of multiple intragenic promoter and/or alternative splicing.; Name=1; Synonyms=A; IsoId=Q9BYB0-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9BYB0-3; Sequence=VSP_053605

Alternative Sequence

76..194; Missing (in isoform 2)

3D Structural Models

Turn

118..120

Helix

91..93; 107..117; 125..127; 149..151; 597..599

Beta Strand

84..90; 95..101; 128..132; 145..148; 156..160; 162..167; 551..553; 561..564; 572..578; 580..588; 591..596; 600..602

3D Structure

NMR spectroscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

1..14; Low complexity; 15..35; Pro residues; 66..78; Gly residues; 482..491; Basic and acidic residues; 514..536; Pro residues; 888..920; Pro residues; 981..990; Pro residues; 1068..1088; Gly residues; 1190..1199; Low complexity; 1248..1268; Basic and acidic residues; 1326..1336; Pro residues; 1435..1445; Basic and acidic residues; 1446..1467; Low complexity; 1519..1535; Low complexity; 1570..1580; Polar residues; 1702..1712; Low complexity; 1713..1732; Pro residues

Repeat

223..253; ANK 1; 257..286; ANK 2; 290..320; ANK 3; 324..353; ANK 4; 357..386; ANK 5; 390..420; ANK 6

Motif

1485..1491; SH3-binding

Coiled Coil

1569..1589

Domain (CC)

In isoform 1, the N-terminal region preceding the ANK repeats interacts with the 6 ANK repeats in an intramolecular manner, thereby restricting access to ligands, such as SHARPIN and SPTAN1..

Domain (FT)

546..605; SH3; 646..740; PDZ; 1743..1806; SAM

Region

1..80; Disordered; 76..150; Intramolecular interaction with the ANK repeats; 482..542; Disordered; 740..764; Disordered; 753..760; Required for interaction with ABI1; 835..928; Disordered; 946..1096; Disordered; 1190..1535; Disordered; 1550..1600; Disordered; 1621..1659; Disordered; 1702..1739; Disordered

Clinical Relevance

Antibody

HPA003446