Protein detail

PAR6G

Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)

Entry name PAR6G	UniProt ID Q9BYG4	EVMP confidence score 0.72
Supporting publications (n) 12	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000178184

Entrez Gene Symbol

PARD6G

Gene Synonym (2)

PAR-6GPAR6gamma

Gene Description

Par-6 family cell polarity regulator gamma

Chromosome

Position

80157232-80247514

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function

GO:0005515 protein binding

KEGG (7)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence12

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PARD6G PRKCZ	Q05513 Q9BYG4	0:0	hu.MAP2
	MARK4 PARD6G PNMA1 PNMA2	Q8ND90 Q96L34 Q9BYG4 Q9UL42	1:1:1:1	CompleatCFinder	Compleat:HC8892

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	4	34771645 27601599 31070281 34571828

Sequence, Structure & Domains11

Sequences

Length

376

Mass

40,883

Sequence

MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYG4-1; Sequence=Displayed; Name=2; IsoId=Q9BYG4-2; Sequence=VSP_047586, VSP_047587

Alternative Sequence

99..107; EEAERGSLG -> DDGALRPGT (in isoform 2); 108..376; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

367..376; Basic and acidic residues

Domain (CC)

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.

Domain (FT)

18..98; PB1; 134..151; Pseudo-CRIB; 158..251; PDZ

Region

127..254; Interaction with PARD3 and CDC42; 356..376; Disordered

Protein Families

PAR6 family

Sequence Similarities

Belongs to the PAR6 family.

Clinical Relevance4

Antibody

HPA047017

Interaction Protein (5)

ENSG00000067606ENSG00000070831ENSG00000124171ENSG00000148498ENSG00000163558

Interaction Count

Interaction Dataset (3)

intact_biogrid_bioplexintact_biogridbiogrid_bioplex

Supporting Publications11

PMID	Title	Abstract
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
29436780	Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
32284825	Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine.	No abstract available
33035814	Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
35611462	Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.	No abstract available
37702715	One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available

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