Protein detail

PAR6G

Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)

Protein symbol PAR6G	UniProt ID Q9BYG4	EVMP score 0.72
Frequency 12	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000178184

Entrez Gene Symbol

PARD6G

Gene Synonym

PAR-6GPAR6gamma

Gene Description

Par-6 family cell polarity regulator gamma

Chromosome

Position

80157232-80247514

Frequency

EVMP Score

0.72

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0005515 protein binding

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PARD6G PRKCZ	Q05513 Q9BYG4	0:0	hu.MAP2
	MARK4 PARD6G PNMA1 PNMA2	Q8ND90 Q96L34 Q9BYG4 Q9UL42	1:1:1:1	CompleatCFinder	Compleat:HC8892

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	4	34771645 27601599 31070281 34571828

Sequence, Structure & Domains

Sequences

Length

376

Mass

40,883

Sequence

MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYG4-1; Sequence=Displayed; Name=2; IsoId=Q9BYG4-2; Sequence=VSP_047586, VSP_047587

Alternative Sequence

99..107; EEAERGSLG -> DDGALRPGT (in isoform 2); 108..376; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

367..376; Basic and acidic residues

Domain (CC)

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.

Domain (FT)

18..98; PB1; 134..151; Pseudo-CRIB; 158..251; PDZ

Region

127..254; Interaction with PARD3 and CDC42; 356..376; Disordered

Protein Families

PAR6 family

Sequence Similarities

Belongs to the PAR6 family.

Clinical Relevance

Antibody

HPA047017

Interaction Protein

ENSG00000067606ENSG00000070831ENSG00000124171ENSG00000148498ENSG00000163558

Interaction Count

Interaction Dataset

intact_biogrid_bioplexintact_biogridbiogrid_bioplex