Protein detail
PAR6G
Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)
Entry name PAR6G | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 12 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
PAR-6GPAR6gamma
Gene Description
Par-6 family cell polarity regulator gamma
Chromosome
18
Position
80157232-80247514
Supporting publications (n)
12
EVMP confidence score
0.72
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function
KEGG (7)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence12
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | No | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (2)
Sequence, Structure & Domains11
Sequences
Length
376
Mass
40,883
Sequence
MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYG4-1; Sequence=Displayed; Name=2; IsoId=Q9BYG4-2; Sequence=VSP_047586, VSP_047587
Alternative Sequence
99..107; EEAERGSLG -> DDGALRPGT (in isoform 2); 108..376; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
367..376; Basic and acidic residues
Domain (CC)
The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
Domain (FT)
18..98; PB1; 134..151; Pseudo-CRIB; 158..251; PDZ
Region
127..254; Interaction with PARD3 and CDC42; 356..376; Disordered
Protein Families
PAR6 family
Sequence Similarities
Belongs to the PAR6 family.
Clinical Relevance4
Antibody
Interaction Protein (5)
ENSG00000067606ENSG00000070831ENSG00000124171ENSG00000148498ENSG00000163558
Interaction Count
5
Interaction Dataset (3)
intact_biogrid_bioplexintact_biogridbiogrid_bioplex