Protein detail

PAR6G

Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)

Entry name PAR6G	UniProt ID Q9BYG4	EVMP confidence score 0.60
Supporting publications (n) 11	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000178184

Entrez Gene Symbol

PARD6G

Gene Synonym (2)

PAR-6GPAR6gamma

Gene Description

Par-6 family cell polarity regulator gamma

Chromosome

Position

80157232-80247514

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function

GO:0005515 protein binding

KEGG (7)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence12

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
tight_junction	tight_junction	GO_Intercell	Yes	Yes
tight_junction	tight_junction	OmniPath	Yes	Yes
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PARD6G PRKCZ	Q05513 Q9BYG4	0:0	hu.MAP2
	MARK4 PARD6G PNMA1 PNMA2	Q8ND90 Q96L34 Q9BYG4 Q9UL42	1:1:1:1	CompleatCFinder	Compleat:HC8892

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	4	34771645 27601599 31070281 34571828

Sequence, Structure & Domains

Sequences

Length

376

Mass

40,883

Sequence

MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYG4-1; Sequence=Displayed; Name=2; IsoId=Q9BYG4-2; Sequence=VSP_047586, VSP_047587

Alternative Sequence

99..107; EEAERGSLG -> DDGALRPGT (in isoform 2); 108..376; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

367..376; Basic and acidic residues

Domain (CC)

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.

Domain (FT)

18..98; PB1; 134..151; Pseudo-CRIB; 158..251; PDZ

Region

127..254; Interaction with PARD3 and CDC42; 356..376; Disordered

Protein Families

PAR6 family

Sequence Similarities

Belongs to the PAR6 family.

Clinical Relevance

Antibody

HPA047017

Interaction Protein (5)

ENSG00000067606ENSG00000070831ENSG00000124171ENSG00000148498ENSG00000163558

Interaction Count

Interaction Dataset (3)

intact_biogrid_bioplexintact_biogridbiogrid_bioplex

Supporting Publications11

PMID	Title	Related sentences
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available

Page 2 of 2Previous