Protein detail

TBD2A

TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)

Entry name TBD2A	UniProt ID Q9BYX2	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000095383

Entrez Gene Symbol

TBC1D2

Gene Synonym

ArmusPARIS1TBC1D2A

Gene Description

TBC1 domain family member 2

Chromosome

Position

98199011-98255649

Frequency

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

24 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AASDH ANKRD36 KRT40 MYH1 MYH4 TBC1D2 TRIM9	A6QL64 P12882 Q4L235 Q6A162 Q9BYX2 Q9C026 Q9Y623	0:0:0:0:0:0:0	hu.MAP
ANKRD36 KRT40 TBC1D2 TRIM9	A6QL64 Q6A162 Q9BYX2 Q9C026	0:0:0:0	hu.MAP
STX16 TBC1D23	O14662 Q9NUY8	2:2	PDB	PDB:8qqf
GABARAP RWDD2A TBC1D25	O95166 Q3MII6 Q9UIY3	0:0:0	hu.MAP2
KRT40 MYH1 TBC1D2 TRIM9	P12882 Q6A162 Q9BYX2 Q9C026	0:0:0:0	hu.MAP
ACBD3 CERK EIF2S3 TBC1D22A	P41091 Q8TCT0 Q8WUA7 Q9H3P7	0:0:0:0	hu.MAP2
CATSPERD HLCS TBC1D20	P50747 Q86XM0 Q96BZ9	0:0:0	hu.MAP2
CERK EFNB3 TBC1D22A	Q15768 Q8TCT0 Q8WUA7	0:0:0	hu.MAP
GABARAPL1 NSMAF TBC1D25	Q3MII6 Q92636 Q9H0R8	0:0:0	hu.MAP2
GABARAPL1 TBC1D25	Q3MII6 Q9H0R8	0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Density Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	1	34817906

Sequence, Structure & Domains

Sequences

Length

928

Mass

105,414

Sequence

MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=A variant C; IsoId=Q9BYX2-1; Sequence=Displayed; Name=2; Synonyms=PARIS-1; IsoId=Q9BYX2-2; Sequence=VSP_039382; Name=3; Synonyms=A; IsoId=Q9BYX2-3; Sequence=VSP_039383; Name=4; IsoId=Q9BYX2-4; Sequence=VSP_039381; Name=5; IsoId=Q9BYX2-5; Sequence=VSP_039380; Name=6; IsoId=Q9BYX2-6; Sequence=VSP_039379

Alternative Sequence

1..460; Missing (in isoform 6); 1..435; MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQ -> MPIPWTAST (in isoform 5); 1..218; Missing (in isoform 4); 820..830; Missing (in isoform 2); 861..928; Missing (in isoform 3)

3D Structural Models

Turn

73..76

Helix

95..97; 106..108; 127..146

Beta Strand

49..54; 58..61; 65..72; 77..83; 90..94; 99..102; 110..114; 120..123; 149..151

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

1..19; Low complexity

Coiled Coil

298..416; 875..913

Domain (FT)

45..142; PH; 625..817; Rab-GAP TBC

Region

1..169; Interaction with CADH1; 1..39; Disordered; 225..275; Disordered; 295..433; Interaction with RAC1

Clinical Relevance

Antibody

HPA030871 HPA076521