Protein detail

TBD2A

TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)

Entry name TBD2A	UniProt ID Q9BYX2	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000095383

Entrez Gene Symbol

TBC1D2

Gene Synonym (3)

ArmusPARIS1TBC1D2A

Gene Description

TBC1 domain family member 2

Chromosome

Position

98199011-98255649

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Reactome (4)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence31

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Protein Complex Composition (24)

24 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AASDH KRT40 TBC1D2 TRIM9	Q4L235 Q6A162 Q9BYX2 Q9C026	0:0:0:0	hu.MAP
FAM91A1 TBC1D23	Q658Y4 Q9NUY8	2:2	PDB	PDB:8jj9
KRT40 TBC1D2	Q6A162 Q9BYX2	0:0	hu.MAPhu.MAP2
KRT40 TBC1D2 TRIM9 TXLNG	Q6A162 Q9BYX2 Q9C026 Q9NUQ3	0:0:0:0	hu.MAP
KRT40 MYH4 TBC1D2 TRIM9	Q6A162 Q9BYX2 Q9C026 Q9Y623	0:0:0:0	hu.MAP
KRT40 MYH4 TBC1D2	Q6A162 Q9BYX2 Q9Y623	0:0:0	hu.MAP
CERK TBC1D22A	Q8TCT0 Q8WUA7	0:0	hu.MAPhu.MAP2
ACBD3 CERK TBC1D22A	Q8TCT0 Q8WUA7 Q9H3P7	0:0:0	hu.MAP2
TBC1D22A	Q8WUA7	2	PDB	PDB:2qfz
TBC1D22A TBC1D22B	Q8WUA7 Q9NU19	0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Density Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	1	34817906

Sequence, Structure & Domains13

Sequences

Length

928

Mass

105,414

Sequence

MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=A variant C; IsoId=Q9BYX2-1; Sequence=Displayed; Name=2; Synonyms=PARIS-1; IsoId=Q9BYX2-2; Sequence=VSP_039382; Name=3; Synonyms=A; IsoId=Q9BYX2-3; Sequence=VSP_039383; Name=4; IsoId=Q9BYX2-4; Sequence=VSP_039381; Name=5; IsoId=Q9BYX2-5; Sequence=VSP_039380; Name=6; IsoId=Q9BYX2-6; Sequence=VSP_039379

Alternative Sequence

1..460; Missing (in isoform 6); 1..435; MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQ -> MPIPWTAST (in isoform 5); 1..218; Missing (in isoform 4); 820..830; Missing (in isoform 2); 861..928; Missing (in isoform 3)

3D Structural Models

Turn

73..76

Helix

95..97; 106..108; 127..146

Beta Strand

49..54; 58..61; 65..72; 77..83; 90..94; 99..102; 110..114; 120..123; 149..151

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

1..19; Low complexity

Coiled Coil

298..416; 875..913

Domain (FT)

45..142; PH; 625..817; Rab-GAP TBC

Region

1..169; Interaction with CADH1; 1..39; Disordered; 225..275; Disordered; 295..433; Interaction with RAC1

Clinical Relevance1

Antibody (2)

HPA030871 HPA076521

Supporting Publications2

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available