Protein detail
RTN4R
Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor)
Entry name RTN4R | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor)
Protein Function (2)
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
Ensembl
Entrez Gene Symbol
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization6
Tissue SpecificretinaCell SpecificCone photoreceptor cellsSingle-Nuclei Brain SpecificsplatterBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function (2)
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
Cellular Component (13)
- GO:0005783 endoplasmic reticulum
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0043198 dendritic shaft
- GO:0043204 perikaryon
- GO:0044295 axonal growth cone
- GO:0045121 membrane raft
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Molecular Function (8)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence43
Ligand-Receptor Signaling (42)
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | HPMR | No | No | No | No | Yes |
| extracellular | extracellular | DGIdb | No | No | No | No | Yes |
| extracellular | extracellular | OmniPath | No | No | No | No | Yes |
| intracellular | intracellular | LOCATE | No | No | No | No | Yes |
| intracellular | intracellular | ComPPI | No | No | No | No | Yes |
| intracellular | intracellular | GO_Intercell | No | No | No | No | Yes |
| intracellular | intracellular | UniProt_location | No | No | No | No | Yes |
| intracellular | intracellular | OmniPath | No | No | No | No | Yes |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | No | Yes |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | No | Yes |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 29635386 |
Sequence, Structure & Domains13
Sequences
Length
473
Mass
50,708
Sequence
MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
3D Structural Models
Turn
74..79; 98..103; 123..128; 147..152; 171..176; 195..200; 219..224
Helix
243..246; 266..268; 269..277; 291..293; 298..300; 303..305
Beta Strand
32..34; 36..38; 40..42; 60..63; 85..87; 109..111; 134..136; 158..160; 182..184; 206..208; 230..232; 254..256; 280..282; 286..290
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
413..429; Basic residues; 434..445; Gly residues
Repeat
55..79; LRR 1; 81..103; LRR 2; 104..128; LRR 3; 129..152; LRR 4; 153..176; LRR 5; 178..200; LRR 6; 202..224; LRR 7; 225..248; LRR 8; 250..273; LRR 9
Domain (FT)
27..54; LRRNT; 260..310; LRRCT
Region
346..447; Disordered
Protein Families
Nogo receptor family
Sequence Similarities
Belongs to the Nogo receptor family.
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 32468033 | Quantitative proteomic characterization of microvesicles/exosomes from the cerebrospinal fluid of patients with acute bilirubin encephalopathy. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |