Protein detail
RTN4R
Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor)
Protein symbol RTN4R | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count | Protein classification |
Basic Information
Protein Names
Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor)
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
Ensembl
Entrez Gene Symbol
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificretinaCell SpecificCone photoreceptor cellsSingle-Nuclei Brain SpecificsplatterBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
Cellular Component
- GO:0005783 endoplasmic reticulum
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0043198 dendritic shaft
- GO:0043204 perikaryon
- GO:0044295 axonal growth cone
- GO:0045121 membrane raft
- GO:0070062 extracellular exosome
- GO:0098793 presynapse
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | No | Yes |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | Yes |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | Yes |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | Yes |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | Yes |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | No | Yes |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | Yes |
| transmembrane | transmembrane | OmniPath | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | Yes |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 29635386 |
Sequence, Structure & Domains
Sequences
Length
473
Mass
50,708
Sequence
MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
3D Structural Models
Turn
74..79; 98..103; 123..128; 147..152; 171..176; 195..200; 219..224
Helix
243..246; 266..268; 269..277; 291..293; 298..300; 303..305
Beta Strand
32..34; 36..38; 40..42; 60..63; 85..87; 109..111; 134..136; 158..160; 182..184; 206..208; 230..232; 254..256; 280..282; 286..290
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
413..429; Basic residues; 434..445; Gly residues
Repeat
55..79; LRR 1; 81..103; LRR 2; 104..128; LRR 3; 129..152; LRR 4; 153..176; LRR 5; 178..200; LRR 6; 202..224; LRR 7; 225..248; LRR 8; 250..273; LRR 9
Domain (FT)
27..54; LRRNT; 260..310; LRRCT
Region
346..447; Disordered
Protein Families
Nogo receptor family
Sequence Similarities
Belongs to the Nogo receptor family.