Protein detail
S19A3
Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)
Protein symbol S19A3 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Transmembrane
8..28; Helical; 54..74; Helical; 82..102; Helical; 111..131; Helical; 145..165; Helical; 170..190; Helical; 283..303; Helical; 317..337; Helical; 343..363; Helical; 376..396; Helical; 406..426; Helical; 435..455; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
THTR2
Gene Description
Solute carrier family 19 member 3
Chromosome
2
Position
227683763-227718028
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAdipocytes
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Cellular Component
Biological Process
Reactome
Canonical Pathways
- M241 Pid rac1 reg pathway
- M68 Pid rhoa reg pathway
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| mfs | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| slc19 | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
496
Mass
55,665
Sequence
MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL
3D Structural Models
Turn
42..44; 54..56; 77..79; 309..311; 428..431
Helix
13..27; 32..34; 35..39; 48..53; 57..76; 80..99; 103..118; 120..130; 133..135; 136..163; 169..187; 262..270; 272..274; 276..306; 316..336; 341..365; 369..394; 400..424; 435..454; 459..464
Beta Strand
100..102; 197..199
3D Structure
Electron microscopy (19)
Domain & Motif Annotations
Region
468..496; Disordered
Protein Families
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Sequence Similarities
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.