Protein detail

S19A3

Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)

Entry name S19A3	UniProt ID Q9BZV2	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)

Protein Class (6)

Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Transmembrane

8..28; Helical; 54..74; Helical; 82..102; Helical; 111..131; Helical; 145..165; Helical; 170..190; Helical; 283..303; Helical; 317..337; Helical; 343..363; Helical; 376..396; Helical; 406..426; Helical; 435..455; Helical

Transmembrane Count

Ensembl

ENSG00000135917

Entrez Gene Symbol

SLC19A3

Gene Synonym

THTR2

Gene Description

Solute carrier family 19 member 3

Chromosome

Position

227683763-227718028

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificAdipocytes

Function & Pathway8

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG

hsa04977 Vitamin digestion and absorption

Reactome (3)

Canonical Pathways (2)

M241 Pid rac1 reg pathway
M68 Pid rhoa reg pathway

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence21

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	38731868 33709510

Sequence, Structure & Domains10

Sequences

Length

496

Mass

55,665

Sequence

MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL

3D Structural Models

Turn

42..44; 54..56; 77..79; 309..311; 428..431

Helix

13..27; 32..34; 35..39; 48..53; 57..76; 80..99; 103..118; 120..130; 133..135; 136..163; 169..187; 262..270; 272..274; 276..306; 316..336; 341..365; 369..394; 400..424; 435..454; 459..464

Beta Strand

100..102; 197..199

3D Structure

Electron microscopy (19)

Domain & Motif Annotations

Region

468..496; Disordered

Protein Families

Reduced folate carrier (RFC) transporter (TC 2.A.48) family

Sequence Similarities

Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.

Clinical Relevance3

Disease Involvement

Disease variant

Drugs

METFORMIN

Antibody

HPA038898

Supporting Publications2

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available
39996590	Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.	No abstract available