Protein detail

S19A3

Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)

Entry name
S19A3
UniProt ID
Q9BZV2
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
12
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Potential drug targets
  • Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Transmembrane
8..28; Helical; 54..74; Helical; 82..102; Helical; 111..131; Helical; 145..165; Helical; 170..190; Helical; 283..303; Helical; 317..337; Helical; 343..363; Helical; 376..396; Helical; 406..426; Helical; 435..455; Helical
Transmembrane Count
12
Ensembl
ENSG00000135917
Entrez Gene Symbol
SLC19A3
Gene Synonym
THTR2
Gene Description
Solute carrier family 19 member 3
Chromosome
2
Position
227683763-227718028
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificAdipocytes
Function & Pathway
Protein Function (4)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Potential drug targets
  • Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Cellular Component (2)
Molecular Function (2)
Biological Process (3)
KEGG
hsa04977 Vitamin digestion and absorption
Reactome (3)
Canonical Pathways (2)
  • M241 Pid rac1 reg pathway
  • M68 Pid rhoa reg pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence21

Ligand-Receptor Signaling (20)

20 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneTopDB
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
cell_surfacecell_surfaceSurfaceome
cell_surfacecell_surfaceOmniPath
receptorreceptorscConnectYes
transmembranetransmembrane_predictedPhobius
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationWestern blotting23873186833709510
Sequence, Structure & Domains

Sequences

Length
496
Mass
55,665
Sequence
MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL

3D Structural Models

Turn
42..44; 54..56; 77..79; 309..311; 428..431
Helix
13..27; 32..34; 35..39; 48..53; 57..76; 80..99; 103..118; 120..130; 133..135; 136..163; 169..187; 262..270; 272..274; 276..306; 316..336; 341..365; 369..394; 400..424; 435..454; 459..464
Beta Strand
100..102; 197..199
3D Structure
Electron microscopy (19)

Domain & Motif Annotations

Region
468..496; Disordered
Protein Families
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Sequence Similarities
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
Clinical Relevance
Disease Involvement
Disease variant
Drugs
METFORMIN
Antibody
HPA038898
Supporting Publications2
PMIDTitleRelated sentences
38037300Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.No related sentences available
39996590Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.No related sentences available