Protein detail

ZDHC5

Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)

Protein symbol ZDHC5	UniProt ID Q9C0B5	EVMP score 0.50
Frequency 3	Transmembrane count 4	Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)

Protein Class

EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Transmembrane

14..34; Helical; 39..59; Helical; 149..169; Helical; 192..212; Helical

Transmembrane Count

Ensembl

ENSG00000156599

Entrez Gene Symbol

ZDHHC5

Gene Synonym

DHHC5KIAA1748ZNF375

Gene Description

Zinc finger DHHC-type palmitoyltransferase 5

Chromosome

Position

57667747-57701182

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificeosinophil

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ZDHHC5	EGF	P01133	S	338	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983
ZDHHC5	FYN	P06241	Y	533	phosphorylation	RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:26334723
ZDHHC5	DLG4	P78352	Y	533	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:26334723

Ligand-Receptor Signaling

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_enzyme	cell_surface_enzyme	Surfaceome	Yes	No	No	Yes	No
cell_surface_enzyme	cell_surface_enzyme	OmniPath	Yes	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ZDHC5	Q9C0B5	EZH2	Q15910	Yes	No	Yes	SIGNOR	SIGNOR:28775165
FYN	P06241	ZDHC5	Q9C0B5	Yes	Yes	No	Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapper	ProtMapper:26334723 ProtMapper:31547976 SIGNOR:26334723
ZDHC5	Q9C0B5	S1PR1	P21453	Yes	Yes	No	SIGNOR	SIGNOR:29185452

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AK6 FKBP4 SARDH UBE2N ZDHHC5	P61088 Q02790 Q9C0B5 Q9UL12 Q9Y3D8	0:0:0:0:0	Havugimana2012	Havugimana2012:C_427
GOLGA7B ZDHHC5	Q2TAP0 Q9C0B5	0:0	hu.MAP2
GOLGA7B SUN2 ZDHHC5	Q2TAP0 Q9C0B5 Q9UH99	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Density Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	2	34817906 28986585

Sequence, Structure & Domains

Sequences

Length

715

Mass

77,545

Sequence

MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLGLATNEDSSLLAKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLGKTPLGRPAVPRFGKPDGLRGRGVGSPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSLGSASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0B5-1; Sequence=Displayed; Name=2; IsoId=Q9C0B5-2; Sequence=VSP_006935

Alternative Sequence

1..53; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

359..373; Low complexity; 422..432; Low complexity; 442..478; Polar residues; 666..677; Polar residues

Domain (CC)

The DHHC domain is required for palmitoyltransferase activity.

Domain (FT)

104..154; DHHC

Region

289..715; Disordered

Protein Families

DHHC palmitoyltransferase family
ERF2/ZDHHC9 subfamily

Sequence Similarities

Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.

Clinical Relevance

Antibody

HPA014670