Protein detail

ZDHC5

Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)

Entry name ZDHC5	UniProt ID Q9C0B5	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 4	Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)

Protein Class (5)

EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Transmembrane

14..34; Helical; 39..59; Helical; 149..169; Helical; 192..212; Helical

Transmembrane Count

Ensembl

ENSG00000156599

Entrez Gene Symbol

ZDHHC5

Gene Synonym (3)

DHHC5KIAA1748ZNF375

Gene Description

Zinc finger DHHC-type palmitoyltransferase 5

Chromosome

Position

57667747-57701182

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificeosinophil

Function & Pathway6

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component (9)

Molecular Function (3)

Biological Process (3)

Reactome (7)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence27

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ZDHHC5	EGF	P01133	S	338	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983
ZDHHC5	FYN	P06241	Y	533	phosphorylation	RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:26334723
ZDHHC5	DLG4	P78352	Y	533	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:26334723

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ZDHC5	Q9C0B5	EZH2	Q15910	Yes	No	Yes	SIGNOR	SIGNOR:28775165
FYN	P06241	ZDHC5	Q9C0B5	Yes	Yes	No	Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapper	ProtMapper:26334723 ProtMapper:31547976 SIGNOR:26334723
ZDHC5	Q9C0B5	S1PR1	P21453	Yes	Yes	No	SIGNOR	SIGNOR:29185452

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AK6 FKBP4 SARDH UBE2N ZDHHC5	P61088 Q02790 Q9C0B5 Q9UL12 Q9Y3D8	0:0:0:0:0	Havugimana2012	Havugimana2012:C_427
GOLGA7B ZDHHC5	Q2TAP0 Q9C0B5	0:0	hu.MAP2
GOLGA7B SUN2 ZDHHC5	Q2TAP0 Q9C0B5 Q9UH99	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Density Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	2	34817906 28986585

Sequence, Structure & Domains11

Sequences

Length

715

Mass

77,545

Sequence

MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLGLATNEDSSLLAKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLGKTPLGRPAVPRFGKPDGLRGRGVGSPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSLGSASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0B5-1; Sequence=Displayed; Name=2; IsoId=Q9C0B5-2; Sequence=VSP_006935

Alternative Sequence

1..53; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

359..373; Low complexity; 422..432; Low complexity; 442..478; Polar residues; 666..677; Polar residues

Domain (CC)

The DHHC domain is required for palmitoyltransferase activity.

Domain (FT)

104..154; DHHC

Region

289..715; Disordered

Protein Families (2)

DHHC palmitoyltransferase family
ERF2/ZDHHC9 subfamily

Sequence Similarities

Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.

Clinical Relevance1

Antibody

HPA014670

Supporting Publications3

PMID	Title	Abstract
26378940	Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis.	No abstract available
27863537	High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.	No abstract available
32944193	Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.	No abstract available