Protein detail

ARP6

Actin-related protein 6 (hArp6) (hARPX)

Entry name ARP6	UniProt ID Q9GZN1	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Actin-related protein 6 (hArp6) (hARPX)

Protein Class

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000075089

Entrez Gene Symbol

ACTR6

Gene Synonym

ARP6FLJ13433

Gene Description

Actin related protein 6

Chromosome

Position

100199122-100241865

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificliverCell SpecificBreast secretory cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa03082 ATP-dependent chromatin remodeling

Canonical Pathways

M11736 Sa mmp cytokine connection

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

16 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACTL6A ACTR5 ACTR6 ACTR8 DKC1 DMAP1 H2AZ1 INO80 INO80C RUVBL1 RUVBL2 TERT VPS72 YEATS4 ZNHIT1	O14746 O43257 O60832 O95619 O96019 P0C0S5 Q15906 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9NPF5 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9594
ACTB ACTL6A ACTR5 ACTR6 ACTR8 DDX5 DIAPH2 H2AZ1 INO80 INO80C RUVBL1 RUVBL2 VPS72 YEATS4 ZNHIT1	O43257 O60879 O95619 O96019 P0C0S5 P17844 P60709 Q15906 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9777
ACTL6A ACTR6 DMAP1 DNAJA2 EP400 H2AZ1 HSP90AA1 KAT5 MRGBP PNKD RUVBL1 RUVBL2 VPS72 YEATS4 ZNHIT1	O43257 O60884 O95619 O96019 P07900 P0C0S5 Q15906 Q8N490 Q92993 Q96L91 Q9GZN1 Q9NPF5 Q9NV56 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9522
ACTL6A ACTL6B ACTR5 ACTR6 ACTR8 COQ9 DMAP1 H2AZ1 INO80 INO80C RUVBL1 RUVBL2 VPS72 YEATS4 ZNHIT1	O43257 O75208 O94805 O95619 O96019 P0C0S5 Q15906 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9NPF5 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8797
ACTB ACTL6A ACTR5 ACTR6 ACTR8 CENPB GFPT2 H2AZ1 INO80 INO80C RUVBL1 RUVBL2 VPS72 YEATS4 ZNHIT1	O43257 O94808 O95619 O96019 P07199 P0C0S5 P60709 Q15906 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9840
ACTL6A ACTR5 ACTR6 ACTR8 DMAP1 H2AZ1 HSPA1L INO80 INO80C RUVBL1 RUVBL2 TANGO6 VPS72 YEATS4 ZNHIT1	O43257 O95619 O96019 P0C0S5 P34931 Q15906 Q6PI98 Q9C0B7 Q9GZN1 Q9H981 Q9H9F9 Q9NPF5 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6023
ACTB ACTL6A ACTR5 ACTR6 ACTR8 FARSB H2AZ1 INO80 INO80C RUVBL1 RUVBL2 SCN10A VPS72 YEATS4 ZNHIT1	O43257 O95619 O96019 P0C0S5 P60709 Q15906 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9NSD9 Q9ULG1 Q9Y230 Q9Y265 Q9Y5Y9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8452
ACTL6A ACTR6 CFDP1 DMAP1 EP400 EPC1 H2AZ1 KAT5 MORF4L2 MRGBP RUVBL1 RUVBL2 VPS72 YEATS4 ZNHIT1	O43257 O95619 O96019 P0C0S5 Q15014 Q15906 Q92993 Q96L91 Q9GZN1 Q9H2F5 Q9NPF5 Q9NV56 Q9UEE9 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9235
ACTL6A ACTR6 H2AZ1 MRGBP RUVBL1 RUVBL2 VPS72 YEATS4 ZNHIT1	O43257 O95619 O96019 P0C0S5 Q15906 Q9GZN1 Q9NV56 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1	CompleatCFinder	Compleat:HC4616
ACTR6 BRD8 DMAP1 EP400 EPC1 EPC2 FOXR2 ING3 JAZF1 KAT5 MBTD1 MRGBP RUVBL1 RUVBL2 TRRAP VPS72 YEATS4 ZNHIT1	O43257 O95619 Q05BQ5 Q15906 Q52LR7 Q6PJQ5 Q86VZ6 Q92993 Q96L91 Q9GZN1 Q9H0E9 Q9H2F5 Q9NPF5 Q9NV56 Q9NXR8 Q9Y230 Q9Y265 Q9Y4A5	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingFlow cytometry	4	41227296 38731868 40098346 40091455

Sequence, Structure & Domains

Sequences

Length

396

Mass

45,810

Sequence

MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9GZN1-1; Sequence=Displayed; Name=2; IsoId=Q9GZN1-2; Sequence=VSP_054637, VSP_054638

Alternative Sequence

127..182; AGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTN -> GEFKFSLKLSYMTMDMNRVILIKSQNIKWHSWLAQWLTPVTPSVWEAEASRSLEFR (in isoform 2); 183..395; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (9)

Domain & Motif Annotations

Protein Families

Actin family
ARP6 subfamily

Sequence Similarities

Belongs to the actin family. ARP6 subfamily.

Clinical Relevance

Antibody

HPA038587 HPA038588

Interaction Protein

ENSG00000106400ENSG00000164032ENSG00000175792ENSG00000183207

Interaction Count

Interaction Dataset

intact_biogrid_bioplexbiogrid_opencell_bioplex