Protein detail

ARP6

Actin-related protein 6 (hArp6) (hARPX)

Entry name ARP6	UniProt ID Q9GZN1	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Actin-related protein 6 (hArp6) (hARPX)

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000075089

Entrez Gene Symbol

ACTR6

Gene Synonym (2)

ARP6FLJ13433

Gene Description

Actin related protein 6

Chromosome

Position

100199122-100241865

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificliverCell SpecificBreast secretory cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function (2)

Biological Process (3)

KEGG

hsa03082 ATP-dependent chromatin remodeling

Canonical Pathways

M11736 Sa mmp cytokine connection

Mediation Categories

Other mediation

Relations & Evidence21

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (16)

16 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACTB ACTL6A ACTR5 ACTR6 ACTR8 CENPA DDX5 H2AX H2AZ1 INO80 INO80C RUVBL1 RUVBL2 VPS72 ZNHIT1	O43257 O96019 P0C0S5 P16104 P17844 P49450 P60709 Q15906 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3982
ACTB ACTL6A ACTR5 ACTR6 ACTR8 FOXD3 H2AX H2AZ1 HSPA1L INO80 INO80C POU5F1 RUVBL1 RUVBL2 ZNHIT1	O43257 O96019 P0C0S5 P16104 P34931 P60709 Q01860 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9UJU5 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9367
ACTL6A ACTR5 ACTR6 ACTR8 DMAP1 H2AX H2AZ1 HSPA1L INO80 INO80C POU5F1 RUVBL1 RUVBL2 VPS72 ZNHIT1	O43257 O96019 P0C0S5 P16104 P34931 Q01860 Q15906 Q6PI98 Q9GZN1 Q9H981 Q9H9F9 Q9NPF5 Q9ULG1 Q9Y230 Q9Y265	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5837
ACTR6 BAHD1 H2BC1 H2BC13 MIER1 ZNHIT1	O43257 Q8N108 Q8TBE0 Q96A08 Q99880 Q9GZN1	0:0:0:0:0:0	hu.MAP2
ACTR6 CCNH CDK7 ERCC2 ERCC3 ERCC4 ERCC5 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 MNAT1 POLR2A TRNT1	P18074 P19447 P24928 P28715 P32780 P50613 P51946 P51948 Q13888 Q13889 Q6ZYL4 Q92759 Q92889 Q96Q11 Q9GZN1	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8734
ACTR6 DMAP1 DPCD RUVBL2	Q9BVM2 Q9GZN1 Q9NPF5 Q9Y230	0:0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingFlow cytometry	4	41227296 38731868 40098346 40091455

Sequence, Structure & Domains8

Sequences

Length

396

Mass

45,810

Sequence

MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9GZN1-1; Sequence=Displayed; Name=2; IsoId=Q9GZN1-2; Sequence=VSP_054637, VSP_054638

Alternative Sequence

127..182; AGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTN -> GEFKFSLKLSYMTMDMNRVILIKSQNIKWHSWLAQWLTPVTPSVWEAEASRSLEFR (in isoform 2); 183..395; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (9)

Domain & Motif Annotations

Protein Families (2)

Actin family
ARP6 subfamily

Sequence Similarities

Belongs to the actin family. ARP6 subfamily.

Clinical Relevance4

Antibody (2)

HPA038587 HPA038588

Interaction Protein (4)

ENSG00000106400ENSG00000164032ENSG00000175792ENSG00000183207

Interaction Count

Interaction Dataset (2)

intact_biogrid_bioplexbiogrid_opencell_bioplex

Supporting Publications2

PMID	Title	Abstract
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available