Protein detail

PAIP1

Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)

Entry name PAIP1	UniProt ID Q9H074	EVMP confidence score 0.60
Supporting publications (n) 14	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000172239

Entrez Gene Symbol

PAIP1

Gene Description

Poly(A) binding protein interacting protein 1

Chromosome

Position

43526267-43557758

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization4

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificBergmann glia

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Reactome (6)

Mediation Categories

Other mediation

Relations & Evidence22

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
WWP2	O00308	PAIP1	Q9H074	Yes	No	Yes	SIGNOR	SIGNOR:25266661

Protein Complex Composition (15)

15 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FAM120A HNRNPDL LARP1B MKRN2 PABPC1L PAIP1 PAIP2 PARP12 ZCCHC3	O14979 Q4VXU2 Q659C4 Q9BPZ3 Q9H000 Q9H074 Q9H0J9 Q9NUD5 Q9NZB2	0:0:0:0:0:0:0:0:0	hu.MAP2
HNRNPDL LARP1B MKRN2 PABPC1L PAIP1 PARP12 ZCCHC3	O14979 Q4VXU2 Q659C4 Q9H000 Q9H074 Q9H0J9 Q9NUD5	0:0:0:0:0:0:0	hu.MAP2
HNRNPDL MKRN2 PABPC1L PAIP1	O14979 Q4VXU2 Q9H000 Q9H074	0:0:0:0	hu.MAP2
HNRNPDL MKRN2 PABPC1L PAIP1 PARP12 ZCCHC3	O14979 Q4VXU2 Q9H000 Q9H074 Q9H0J9 Q9NUD5	0:0:0:0:0:0	hu.MAP2
HNRNPDL PABPC1L PAIP1	O14979 Q4VXU2 Q9H074	0:0:0	hu.MAP2
ATG101 ATG13 PABPC1 PAIP1 ULK2	O75143 P11940 Q8IYT8 Q9BSB4 Q9H074	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8789
ANKRD17 LARP4 PABPC1 PAIP1 PAIP2 ZCCHC3	O75179 P11940 Q71RC2 Q9BPZ3 Q9H074 Q9NUD5	0:0:0:0:0:0	hu.MAP2
PABPC1 PABPC4 PAIP1	P11940 Q13310 Q9H074	0:0:0	hu.MAP2
PABPC1 PAIP1	P11940 Q9H074	1:1	PDB	PDB:1jh4
ELAVL2 PABPC1L PAIP1	Q12926 Q4VXU2 Q9H074	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based Methods	Mass spectrometryR Sequencing	23	31196968 31508500 38225453 39436214 39873726 41227296 40545963 34064456 32795414 25844599 27723984 28242843 29242380 33709510 40619995 30975894 28396511 30760538 40311616 40091455 38564289 41315767 31320591

Sequence, Structure & Domains12

Sequences

Length

479

Mass

53,525

Sequence

MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H074-1; Sequence=Displayed; Name=2; IsoId=Q9H074-2; Sequence=VSP_010005; Name=3; IsoId=Q9H074-3; Sequence=VSP_047503

Alternative Sequence

1..112; Missing (in isoform 3); 10..88; Missing (in isoform 2)

3D Structural Models

Helix

158..171; 173..175; 176..190; 194..209; 215..228; 238..250; 253..256; 261..280; 294..309; 313..336; 341..355; 360..372

Beta Strand

288..291

3D Structure

NMR spectroscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

11..33; Gly residues; 45..69; Pro residues; 98..111; Polar residues

Domain (CC)

Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.

Domain (FT)

159..376; MIF4G

Region

1..114; Disordered; 116..143; PABPC1-interacting motif-2 (PAM2); 157..375; PAIP1 middle domain (PAIP1M); 435..455; Disordered; 440..479; PABPC1-interacting motif-1 (PAM1)

Clinical Relevance4

Antibody (2)

HPA073653 HPA076187

Interaction Protein (2)

ENSG00000070756ENSG00000090621

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell

Supporting Publications14

PMID	Title	Abstract
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
34064677	Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.	No abstract available
34473505	Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available

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