Protein detail
PAIP1
Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)
Entry name PAIP1 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 14 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Poly(A) binding protein interacting protein 1
Chromosome
5
Position
43526267-43557758
Supporting publications (n)
14
EVMP confidence score
0.60
Fluorescence & Localization4
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome (6)
- R-hsa-429914 deadenylation dependent mrna decay
- R-hsa-429947 deadenylation of mrna
- R-hsa-9816359 maternal to zygotic transition mzt
- R-hsa-8953854 metabolism of rna
- R-hsa-9820841 m decay degradation of maternal mrnas by maternally stored factors
- R-hsa-9820865 z decay degradation of maternal mrnas by zygotically expressed factors
Mediation Categories
Other mediation
Relations & Evidence22
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| WWP2 | O00308 | PAIP1 | Q9H074 | Yes | No | Yes | SIGNOR | SIGNOR:25266661 |
Protein Complex Composition (15)
15 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PAIP1PRPF31TFDP1UPF2 | Q14186Q8WWY3Q9H074Q9HAU5 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_261 | ||
| LARP1BPABPC1LPAIP1PAIP2ZCCHC3 | Q4VXU2Q659C4Q9BPZ3Q9H074Q9NUD5 | 0:0:0:0:0 | hu.MAP2 | |||
| PABPC1LPAIP1PAIP2ZCCHC3 | Q4VXU2Q9BPZ3Q9H074Q9NUD5 | 0:0:0:0 | hu.MAP2 | |||
| PABPC1LPAIP1 | Q4VXU2Q9H074 | 0:0 | hu.MAPhu.MAP2 | |||
| PAIP1 | Q9H074 | 2 | PDB | PDB:3rk6 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based Methods | Mass spectrometryR Sequencing | 23 | 3119696831508500382254533943621439873726412272964054596334064456327954142584459927723984282428432924238033709510406199953097589428396511307605384031161640091455385642894131576731320591 |
Sequence, Structure & Domains12
Sequences
Length
479
Mass
53,525
Sequence
MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H074-1; Sequence=Displayed; Name=2; IsoId=Q9H074-2; Sequence=VSP_010005; Name=3; IsoId=Q9H074-3; Sequence=VSP_047503
Alternative Sequence
1..112; Missing (in isoform 3); 10..88; Missing (in isoform 2)
3D Structural Models
Helix
158..171; 173..175; 176..190; 194..209; 215..228; 238..250; 253..256; 261..280; 294..309; 313..336; 341..355; 360..372
Beta Strand
288..291
3D Structure
NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
11..33; Gly residues; 45..69; Pro residues; 98..111; Polar residues
Domain (CC)
Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.
Domain (FT)
159..376; MIF4G
Region
1..114; Disordered; 116..143; PABPC1-interacting motif-2 (PAM2); 157..375; PAIP1 middle domain (PAIP1M); 435..455; Disordered; 440..479; PABPC1-interacting motif-1 (PAM1)
Clinical Relevance4
Supporting Publications14
| PMID | Title | Abstract |
|---|---|---|
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No abstract available |
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No abstract available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 34064677 | Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells. | No abstract available |
| 34473505 | Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles. | No abstract available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
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