Protein detail

REN3A

Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)

Entry name REN3A	UniProt ID Q9H1J1	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000169062

Entrez Gene Symbol

UPF3A

Gene Synonym (3)

HUPF3ARENT3AUPF3

Gene Description

UPF3A regulator of nonsense mediated mRNA decay

Chromosome

Position

114281601-114305817

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Tissue Specificbrain

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories

Other mediation

Relations & Evidence23

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (17)

17 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Postsplicing complex	NXF1 RBM8A RNPS1 UPF1 UPF2 UPF3A UPF3B	Q15287 Q92900 Q9BZI7 Q9H1J1 Q9HAU5 Q9UBU9 Q9Y5S9	1:1:1:1:1:1:1	CompleatCORUM	CORUM:814Compleat:HC2136	11546874
Upf complex (UPF1UPF2UPF3a)	UPF1 UPF2 UPF3A	Q92900 Q9H1J1 Q9HAU5	1:1:1	CompleatCORUM	CORUM:812Compleat:HC966	11163187
exon-exon junction complex	CASC3 EIF4A3 MAGOH POLDIP3 PYM1 RBM8A RNPS1 UPF1 UPF2 UPF3A UPF3B	O15234 P38919 P61326 Q15287 Q92900 Q9BRP8 Q9BY77 Q9BZI7 Q9H1J1 Q9HAU5 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2180	16601204 11546874 11546873 18423201 18026120
	CERK DIS3L EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC8 GPR89A UBC UPF1 UPF2 UPF3A UPF3B	B7ZAQ6 P0CG48 Q01780 Q13868 Q5RKV6 Q8TCT0 Q8TF46 Q92900 Q96B26 Q9BZI7 Q9H1J1 Q9HAU5 Q9NPD3 Q9NQT4 Q9Y3B2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4915
	CA1 CASC3 HBB HBD UPF3A	O15234 P00915 P02042 P68871 Q9H1J1	0:0:0:0:0	hu.MAP2
	A1BG ALB APOA2 APOC3 C3 CA1 CFB GDPD1 HBA2 HBB HBD HBG1 HPX ITIH2 ITIH4 ORM1 ORM2 TF UPF3A	P00751 P00915 P01024 P02042 P02652 P02656 P02763 P02768 P02787 P02790 P04217 P19652 P19823 P68871 P69891 P69905 Q14624 Q8N9F7 Q9H1J1	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	CA1 HBA2 HBB HBD UPF3A	P00915 P02042 P68871 P69905 Q9H1J1	0:0:0:0:0	hu.MAP2
	ALYREF EIF4A3 HNRNPC MAGOH NCBP1 NXF1 PCLAF RBM8A RNPS1 SMG1 SRRM1 UPF1 UPF2 UPF3A UPF3B	P07910 P38919 P61326 Q09161 Q15004 Q15287 Q86V81 Q8IYB3 Q92900 Q96Q15 Q9BZI7 Q9H1J1 Q9HAU5 Q9UBU9 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCFinder	Compleat:HC8896
	ETF1 GSPT1 GSPT2 HNRNPA1 HNRNPA2B1 PABPC1 RBM3 RBM8A SMG1 UBC UPF1 UPF2 UPF3A UPF3B	P09651 P0CG48 P11940 P15170 P22626 P62495 P98179 Q8IYD1 Q92900 Q96Q15 Q9BZI7 Q9H1J1 Q9HAU5 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9500
	EIF4A3 ETF1 GSPT1 GSPT2 HNRNPA1 NCBP1 NXF1 PABPC1 RBM8A SMG1 UBC UPF1 UPF2 UPF3A UPF3B	P09651 P0CG48 P11940 P15170 P38919 P62495 Q09161 Q8IYD1 Q92900 Q96Q15 Q9BZI7 Q9H1J1 Q9HAU5 Q9UBU9 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3843

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing	0

Sequence, Structure & Domains13

Sequences

Length

476

Mass

54,696

Sequence

MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPREEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=hUpf3p, hUPF3L; IsoId=Q9H1J1-1; Sequence=Displayed; Name=2; Synonyms=hUpf3pdelta, hUPF3S; IsoId=Q9H1J1-2; Sequence=VSP_012962; Name=3; IsoId=Q9H1J1-3; Sequence=VSP_012961

Alternative Sequence

1..325; Missing (in isoform 3); 141..173; Missing (in isoform 2)

3D Structural Models

Turn

121..123

Helix

81..87; 124..131; 171..173; 175..184

Beta Strand

69..75; 94..100; 104..106; 112..120; 135..137; 143..145; 147..150

3D Structure

NMR spectroscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

21..38; Basic and acidic residues; 250..304; Basic and acidic residues; 340..401; Basic and acidic residues; 410..437; Basic and acidic residues

Region

1..63; Disordered; 66..140; Required for interaction with UPF2; 250..476; Disordered; 421..434; Required for association with EIF4A3 and ECJ core components CASC3, MAGOH and RBM8A

Protein Families

RENT3 family

Sequence Similarities

Belongs to the RENT3 family.

Clinical Relevance4

Antibody (2)

HPA018325 HPA061316

Interaction Protein (3)

ENSG00000005007ENSG00000151461ENSG00000265241

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No abstract available