Protein detail
REN3A
Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)
Entry name REN3A | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
HUPF3ARENT3AUPF3
Gene Description
UPF3A regulator of nonsense mediated mRNA decay
Chromosome
13
Position
114281601-114305817
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Tissue Specificbrain
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
Reactome (5)
Mediation Categories
Other mediation
Relations & Evidence23
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (17)
17 records.
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing | 0 |
Sequence, Structure & Domains13
Sequences
Length
476
Mass
54,696
Sequence
MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPREEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=hUpf3p, hUPF3L; IsoId=Q9H1J1-1; Sequence=Displayed; Name=2; Synonyms=hUpf3pdelta, hUPF3S; IsoId=Q9H1J1-2; Sequence=VSP_012962; Name=3; IsoId=Q9H1J1-3; Sequence=VSP_012961
Alternative Sequence
1..325; Missing (in isoform 3); 141..173; Missing (in isoform 2)
3D Structural Models
Turn
121..123
Helix
81..87; 124..131; 171..173; 175..184
Beta Strand
69..75; 94..100; 104..106; 112..120; 135..137; 143..145; 147..150
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
21..38; Basic and acidic residues; 250..304; Basic and acidic residues; 340..401; Basic and acidic residues; 410..437; Basic and acidic residues
Region
1..63; Disordered; 66..140; Required for interaction with UPF2; 250..476; Disordered; 421..434; Required for association with EIF4A3 and ECJ core components CASC3, MAGOH and RBM8A
Protein Families
RENT3 family
Sequence Similarities
Belongs to the RENT3 family.
Clinical Relevance4
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40595564 | Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome. | No abstract available |