Protein detail

REN3A

Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)

Entry name REN3A	UniProt ID Q9H1J1	EVMP confidence score 0.28
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000169062

Entrez Gene Symbol

UPF3A

Gene Synonym (3)

HUPF3ARENT3AUPF3

Gene Description

UPF3A regulator of nonsense mediated mRNA decay

Chromosome

Position

114281601-114305817

Supporting publications (n)

EVMP confidence score

0.28

Fluorescence & Localization

Tissue Specificbrain

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories

Other mediation

Relations & Evidence23

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Protein Complex Composition (17)

17 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ETF1 GSPT1 GSPT2 HELZ HNRNPA1 PABPC1 RBM8A SMG1 SMYD3 UBC UPF1 UPF2 UPF3A UPF3B	P09651 P0CG48 P11940 P15170 P42694 P62495 Q8IYD1 Q92900 Q96Q15 Q9BZI7 Q9H1J1 Q9H7B4 Q9HAU5 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8770
EEA1 ETF1 GSPT1 GSPT2 HNRNPA1 HSPA14 PABPC1 RBM8A SLC25A15 SMG1 UBC UPF1 UPF2 UPF3A UPF3B	P09651 P0CG48 P11940 P15170 P62495 Q0VDF9 Q15075 Q8IYD1 Q92900 Q96Q15 Q9BZI7 Q9H1J1 Q9HAU5 Q9Y5S9 Q9Y619	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3726
CERT1 CTBP1 ETF1 GSPT1 GSPT2 HNRNPA1 PABPC1 POM121 RBM8A SMG1 UBC UPF1 UPF2 UPF3A UPF3B	P09651 P0CG48 P11940 P15170 P62495 Q13363 Q8IYD1 Q92900 Q96HA1 Q96Q15 Q9BZI7 Q9H1J1 Q9HAU5 Q9Y5P4 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8866
ETF1 GSPT1 GSPT2 HNRNPA1 PABPC1 PAN2 PAN3 RBM8A SMG1 UBC UPF1 UPF2 UPF3A UPF3B	P09651 P0CG48 P11940 P15170 P62495 Q504Q3 Q58A45 Q8IYD1 Q92900 Q96Q15 Q9BZI7 Q9H1J1 Q9HAU5 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4418
ARFGAP3 ETF1 GSPT1 GSPT2 HNRNPA1 MOV10 PABPC1 RBM8A SMG1 UBC UPF1 UPF2 UPF3A UPF3B	P09651 P0CG48 P11940 P15170 P62495 Q8IYD1 Q92900 Q96Q15 Q9BZI7 Q9H1J1 Q9HAU5 Q9HCE1 Q9NP61 Q9Y5S9	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6180
NXF1 RBM8A RNPS1 SRRM1 UPF1 UPF3A	Q15287 Q8IYB3 Q92900 Q9H1J1 Q9UBU9 Q9Y5S9	1:1:1:1:1:1	CompleatCFinder	Compleat:HC9879
UPF2 UPF3A	Q9H1J1 Q9HAU5	4:4	PDB	PDB:7qg6

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)R Sequencing	0

Sequence, Structure & Domains

Sequences

Length

476

Mass

54,696

Sequence

MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPREEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=hUpf3p, hUPF3L; IsoId=Q9H1J1-1; Sequence=Displayed; Name=2; Synonyms=hUpf3pdelta, hUPF3S; IsoId=Q9H1J1-2; Sequence=VSP_012962; Name=3; IsoId=Q9H1J1-3; Sequence=VSP_012961

Alternative Sequence

1..325; Missing (in isoform 3); 141..173; Missing (in isoform 2)

3D Structural Models

Turn

121..123

Helix

81..87; 124..131; 171..173; 175..184

Beta Strand

69..75; 94..100; 104..106; 112..120; 135..137; 143..145; 147..150

3D Structure

NMR spectroscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

21..38; Basic and acidic residues; 250..304; Basic and acidic residues; 340..401; Basic and acidic residues; 410..437; Basic and acidic residues

Region

1..63; Disordered; 66..140; Required for interaction with UPF2; 250..476; Disordered; 421..434; Required for association with EIF4A3 and ECJ core components CASC3, MAGOH and RBM8A

Protein Families

RENT3 family

Sequence Similarities

Belongs to the RENT3 family.

Clinical Relevance

Antibody (2)

HPA018325 HPA061316

Interaction Protein (3)

ENSG00000005007ENSG00000151461ENSG00000265241

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Related sentences
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No related sentences available