Protein detail
EHD4
EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4)
Entry name EHD4 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 33 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
PAST4
Gene Description
EH domain containing 4
Chromosome
15
Position
41895933-41972557
Supporting publications (n)
33
EVMP confidence score
0.88
Fluorescence & Localization8
Tissue Specificbone marrowBrain Regional Specificcerebral cortexCell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificclassical monocyteBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionImmunity
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (11)
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005769 early endosome
- GO:0005783 endoplasmic reticulum
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0030139 endocytic vesicle
- GO:0031901 early endosome membrane
- GO:0048471 perinuclear region of cytoplasm
- GO:0055038 recycling endosome membrane
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Molecular Function (6)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence12
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EHD4 | EGFR | P00533 | Y | 456 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | R Sequencing | 1 | 37740815 |
Sequence, Structure & Domains8
Sequences
Length
541
Mass
61,175
Sequence
MFSWMGRQAGGRERAGGADAVQTVTGGLRSLYLRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKISPLMNLISQEETSTPTQLVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPSSLPPHLVPPSHRKSLPKAD
Domain & Motif Annotations
Domain (CC)
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Domain (FT)
58..289; Dynamin-type G; 447..535; EH; 479..514; EF-hand
Region
68..75; G1 motif; 94..95; G2 motif; 156..159; G3 motif; 222..225; G4 motif; 246; G5 motif
Protein Families (3)
- TRAFAC class dynamin-like GTPase superfamily
- Dynamin/Fzo/YdjA family
- EHD subfamily
Sequence Similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
Supporting Publications33
| PMID | Title | Abstract |
|---|---|---|
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |
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