Protein detail
S38A1
Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)
Protein symbol S38A1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 11 | Protein classification FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)
Protein Class
FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
75..97; Helical; 113..133; Helical; 148..168; Helical; 189..211; Helical; 217..237; Helical; 276..296; Helical; 313..333; Helical; 351..371; Helical; 394..414; Helical; 417..437; Helical; 453..473; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym
ATA1NAT2SAT1
Gene Description
Solute carrier family 38 member 1
Chromosome
12
Position
46183063-46270017
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cells
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0005283 amino acid:sodium symporter activity
- GO:0005295 neutral L-amino acid:sodium symporter activity
- GO:0005298 proline:sodium symporter activity
- GO:0005515 protein binding
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015175 neutral L-amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015186 L-glutamine transmembrane transporter activity
- GO:0015375 glycine:sodium symporter activity
- GO:0015655 alanine:sodium symporter activity
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| apc | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc38 | transporter | Surfaceome | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 34889606 |
Sequence, Structure & Domains
Sequences
Length
487
Mass
54,048
Sequence
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH
3D Structural Models
Domain & Motif Annotations
Protein Families
Amino acid/polyamine transporter 2 family
Sequence Similarities
Belongs to the amino acid/polyamine transporter 2 family.