Protein detail

S38A1

Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)

Entry name S38A1	UniProt ID Q9H2H9	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 11	Protein classification FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (5)

FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (3)

Transporters:Electrochemical Potential-driven transporters
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Transmembrane

75..97; Helical; 113..133; Helical; 148..168; Helical; 189..211; Helical; 217..237; Helical; 276..296; Helical; 313..333; Helical; 351..371; Helical; 394..414; Helical; 417..437; Helical; 453..473; Helical

Transmembrane Count

Ensembl

ENSG00000111371

Entrez Gene Symbol

SLC38A1

Gene Synonym (3)

ATA1NAT2SAT1

Gene Description

Solute carrier family 38 member 1

Chromosome

Position

46183063-46270017

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificAdrenal medulla cells

Function & Pathway7

Protein Function (3)

Transporters:Electrochemical Potential-driven transporters
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Cellular Component (7)

Molecular Function (10)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence21

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
transporter	transporter	Surfaceome	No	Yes	No	Yes	No
apc	transporter	Surfaceome	No	Yes	No	Yes	No
slc	transporter	Surfaceome	No	Yes	No	Yes	No
slc38	transporter	Surfaceome	No	Yes	No	Yes	No
transporter	transporter	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	34889606

Sequence, Structure & Domains5

Sequences

Length

487

Mass

54,048

Sequence

MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH

Domain & Motif Annotations

Protein Families

Amino acid/polyamine transporter 2 family

Sequence Similarities

Belongs to the amino acid/polyamine transporter 2 family.

Clinical Relevance7

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

ALANINE

Antibody (2)

HPA039460 HPA052272

Interaction Protein

ENSG00000154723

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
38341434	Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding.	MT1-MMP recruits TKS4/5 into multivesicular endosomes for their subsequent co-secretion in extracellular vesicles, together with the enzymatically active ectodomain.