Protein detail

S38A1

Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)

Entry name S38A1	UniProt ID Q9H2H9	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 11	Protein classification FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (5)

FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (3)

Transporters:Electrochemical Potential-driven transporters
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Transmembrane

75..97; Helical; 113..133; Helical; 148..168; Helical; 189..211; Helical; 217..237; Helical; 276..296; Helical; 313..333; Helical; 351..371; Helical; 394..414; Helical; 417..437; Helical; 453..473; Helical

Transmembrane Count

Ensembl

ENSG00000111371

Entrez Gene Symbol

SLC38A1

Gene Synonym (3)

ATA1NAT2SAT1

Gene Description

Solute carrier family 38 member 1

Chromosome

Position

46183063-46270017

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificAdrenal medulla cells

Function & Pathway7

Protein Function (3)

Transporters:Electrochemical Potential-driven transporters
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Cellular Component (7)

Molecular Function (10)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence21

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	34889606

Sequence, Structure & Domains5

Sequences

Length

487

Mass

54,048

Sequence

MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH

Domain & Motif Annotations

Protein Families

Amino acid/polyamine transporter 2 family

Sequence Similarities

Belongs to the amino acid/polyamine transporter 2 family.

Clinical Relevance7

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

ALANINE

Antibody (2)

HPA039460 HPA052272

Interaction Protein

ENSG00000154723

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
38341434	Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding.	MT1-MMP recruits TKS4/5 into multivesicular endosomes for their subsequent co-secretion in extracellular vesicles, together with the enzymatically active ectodomain.