Protein detail

TM245

Transmembrane protein 245 (Protein CG-2)

Entry name TM245	UniProt ID Q9H330	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 14	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Transmembrane protein 245 (Protein CG-2)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

60..80; Helical; 119..139; Helical; 148..168; Helical; 185..205; Helical; 219..239; Helical; 241..261; Helical; 354..374; Helical; 377..397; Helical; 460..480; Helical; 626..646; Helical; 650..670; Helical; 732..752; Helical; 776..796; Helical; 815..835; Helical

Transmembrane Count

Ensembl

ENSG00000106771

Entrez Gene Symbol

TMEM245

Gene Synonym (2)

C9orf5CG-2

Gene Description

Transmembrane protein 245

Chromosome

Position

109015135-109119947

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Cell SpecificBreast myoepithelial cellsSingle-Nuclei Brain SpecificpericyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0003674 molecular_function

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence15

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TMEM245	CDK1	P06493	S	332	phosphorylation	KEA	KEA:17570479
TMEM245	MAPK8	P45983	S	332	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	LYPD6 TMEM245 TMEM68	Q86Y78 Q96MH6 Q9H330	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryFlow cytometryMORPH	6	40619995 30760538 31320591 41216884 38136601 30451371

Sequence, Structure & Domains9

Sequences

Length

879

Mass

97,357

Sequence

MADGGGPKDAPSLRSSPGPAPRVPRAVGPSGGGGETPRTAALALRFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIVLAALLLPLCFVDYGVEALGEQALRRRRLLLLLGAGGPLLYGLYCLGSYLGVQVLLVHAATLICRGLDYFSSLWIWTLVVGYVLTVSFKWNASTERYLRAVSIPVWIILLFHLASLAGSWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLANLAISITGYESSSEDQPSTQPAEAVDRGESAPTLSTSPSPSSPSPTSPSPTLGRRRPEIGTFLRKKKTSDIYFVSLVWAIVVMQIWLNLWIVQLLPVPIAVWILKKLVIHFGVVDFLEKRYHVWWGIIESFLKERQGALAPWPIVGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVTHSGRHKGQKLHVSRQNSWLGDILDWQDIVSFVHENIETFLSILESLWIVMSRNVSLLFTTVTTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTMFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLIFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQTPWPAQPQRTFRDISEDLKSSVG

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q9H330-2; Sequence=Displayed; Name=3; IsoId=Q9H330-3; Sequence=VSP_014680; Name=4; IsoId=Q9H330-4; Sequence=VSP_059402, VSP_059403, VSP_059404

Alternative Sequence

1..448; Missing (in isoform 3); 440..447; Missing (in isoform 4); 511; N -> K (in isoform 4); 512..879; Missing (in isoform 4)

Domain & Motif Annotations

Compositional Bias

293..304; Polar residues

Region

1..36; Disordered; 293..339; Disordered

Protein Families

Autoinducer-2 exporter (AI-2E) (TC 2.A.86) family

Sequence Similarities

Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.

Clinical Relevance1

Antibody

HPA023892

Supporting Publications1

PMID	Title	Abstract
40748658	Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.	No abstract available