Protein detail

TM245

Transmembrane protein 245 (Protein CG-2)

Entry name TM245	UniProt ID Q9H330	EVMP score 0.50
Frequency 1	Transmembrane count 14	Protein classification Predicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Transmembrane protein 245 (Protein CG-2)

Protein Class

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

60..80; Helical; 119..139; Helical; 148..168; Helical; 185..205; Helical; 219..239; Helical; 241..261; Helical; 354..374; Helical; 377..397; Helical; 460..480; Helical; 626..646; Helical; 650..670; Helical; 732..752; Helical; 776..796; Helical; 815..835; Helical

Transmembrane Count

Ensembl

ENSG00000106771

Entrez Gene Symbol

TMEM245

Gene Synonym

C9orf5CG-2

Gene Description

Transmembrane protein 245

Chromosome

Position

109015135-109119947

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificBreast myoepithelial cellsSingle-Nuclei Brain SpecificpericyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0003674 molecular_function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TMEM245	CDK1	P06493	S	332	phosphorylation	KEA	KEA:17570479
TMEM245	MAPK8	P45983	S	332	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No

Page 1 of 2Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	LYPD6 TMEM245 TMEM68	Q86Y78 Q96MH6 Q9H330	0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryFlow cytometryMORPH	6	40619995 30760538 31320591 41216884 38136601 30451371

Sequence, Structure & Domains

Sequences

Length

879

Mass

97,357

Sequence

MADGGGPKDAPSLRSSPGPAPRVPRAVGPSGGGGETPRTAALALRFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIVLAALLLPLCFVDYGVEALGEQALRRRRLLLLLGAGGPLLYGLYCLGSYLGVQVLLVHAATLICRGLDYFSSLWIWTLVVGYVLTVSFKWNASTERYLRAVSIPVWIILLFHLASLAGSWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLANLAISITGYESSSEDQPSTQPAEAVDRGESAPTLSTSPSPSSPSPTSPSPTLGRRRPEIGTFLRKKKTSDIYFVSLVWAIVVMQIWLNLWIVQLLPVPIAVWILKKLVIHFGVVDFLEKRYHVWWGIIESFLKERQGALAPWPIVGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVTHSGRHKGQKLHVSRQNSWLGDILDWQDIVSFVHENIETFLSILESLWIVMSRNVSLLFTTVTTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTMFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLIFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQTPWPAQPQRTFRDISEDLKSSVG

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q9H330-2; Sequence=Displayed; Name=3; IsoId=Q9H330-3; Sequence=VSP_014680; Name=4; IsoId=Q9H330-4; Sequence=VSP_059402, VSP_059403, VSP_059404

Alternative Sequence

1..448; Missing (in isoform 3); 440..447; Missing (in isoform 4); 511; N -> K (in isoform 4); 512..879; Missing (in isoform 4)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

293..304; Polar residues

Region

1..36; Disordered; 293..339; Disordered

Protein Families

Autoinducer-2 exporter (AI-2E) (TC 2.A.86) family

Sequence Similarities

Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.

Clinical Relevance

Antibody

HPA023892