Protein detail

TM245

Transmembrane protein 245 (Protein CG-2)

Entry name TM245	UniProt ID Q9H330	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 14	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Transmembrane protein 245 (Protein CG-2)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

60..80; Helical; 119..139; Helical; 148..168; Helical; 185..205; Helical; 219..239; Helical; 241..261; Helical; 354..374; Helical; 377..397; Helical; 460..480; Helical; 626..646; Helical; 650..670; Helical; 732..752; Helical; 776..796; Helical; 815..835; Helical

Transmembrane Count

Ensembl

ENSG00000106771

Entrez Gene Symbol

TMEM245

Gene Synonym (2)

C9orf5CG-2

Gene Description

Transmembrane protein 245

Chromosome

Position

109015135-109119947

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Cell SpecificBreast myoepithelial cellsSingle-Nuclei Brain SpecificpericyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0003674 molecular_function

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence15

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TMEM245	CDK1	P06493	S	332	phosphorylation	KEA	KEA:17570479
TMEM245	MAPK8	P45983	S	332	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	LYPD6 TMEM245 TMEM68	Q86Y78 Q96MH6 Q9H330	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryFlow cytometryMORPH	6	40619995 30760538 31320591 41216884 38136601 30451371

Sequence, Structure & Domains9

Sequences

Length

879

Mass

97,357

Sequence

MADGGGPKDAPSLRSSPGPAPRVPRAVGPSGGGGETPRTAALALRFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLTRLGRHWLQRLHRAHTPIVLAALLLPLCFVDYGVEALGEQALRRRRLLLLLGAGGPLLYGLYCLGSYLGVQVLLVHAATLICRGLDYFSSLWIWTLVVGYVLTVSFKWNASTERYLRAVSIPVWIILLFHLASLAGSWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVISMAASTLANLAISITGYESSSEDQPSTQPAEAVDRGESAPTLSTSPSPSSPSPTSPSPTLGRRRPEIGTFLRKKKTSDIYFVSLVWAIVVMQIWLNLWIVQLLPVPIAVWILKKLVIHFGVVDFLEKRYHVWWGIIESFLKERQGALAPWPIVGLGKFLLKVDSKLWHWLNKKMIIWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPEWANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDRLYHSWFVKNVTHSGRHKGQKLHVSRQNSWLGDILDWQDIVSFVHENIETFLSILESLWIVMSRNVSLLFTTVTTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKWVISLTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTMFGINIVFIPSALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLIFHLLPTYFVDTAIYSDISGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQTPWPAQPQRTFRDISEDLKSSVG

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q9H330-2; Sequence=Displayed; Name=3; IsoId=Q9H330-3; Sequence=VSP_014680; Name=4; IsoId=Q9H330-4; Sequence=VSP_059402, VSP_059403, VSP_059404

Alternative Sequence

1..448; Missing (in isoform 3); 440..447; Missing (in isoform 4); 511; N -> K (in isoform 4); 512..879; Missing (in isoform 4)

Domain & Motif Annotations

Compositional Bias

293..304; Polar residues

Region

1..36; Disordered; 293..339; Disordered

Protein Families

Autoinducer-2 exporter (AI-2E) (TC 2.A.86) family

Sequence Similarities

Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.

Clinical Relevance1

Antibody

HPA023892

Supporting Publications1

PMID	Title	Abstract
40748658	Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.	No abstract available