Protein detail
SEM6B
Semaphorin-6B (Semaphorin-Z) (Sema Z)
Protein symbol SEM6B | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Semaphorin-6B (Semaphorin-Z) (Sema Z)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
Transmembrane
604..624; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
SEM-SEMA-ZSEMA-VIBSEMANsemaZ
Gene Description
Semaphorin 6B
Chromosome
19
Position
4542593-4581776
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytes
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M247 Pid insulin glucose pathway
- M232 Pid ecadherin stabilization pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| semaphorin | cell_surface_ligand | HGNC | Yes | No | No | Yes | No |
| semaphorin | cell_surface_ligand | Almen2009 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
888
Mass
95,285
Sequence
MQTPRASPPRPALLLLLLLLGGAHGLFPEEPPPLSVAPRDYLNHYPVFVGSGPGRLTPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAFEQDVSGASTSGLGDCTGLLRASLSEDRAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWFVGLRERRELARRKDKEAILAHGAGEAVLSVSRLGERRAQGPGGRGGGGGGGAGVPPEALLAPLMQNGWAKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEPTPDGRLYAARPGRASHGDFPLTPHASPDRRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTHTFNSGEARPGDRHRGCHARPGTDLAHLLPYGGADRTAPPVP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H3T3-1; Sequence=Displayed; Name=2; IsoId=Q9H3T3-3; Sequence=VSP_047625, VSP_047626
Alternative Sequence
620..677; WFVGLRERRELARRKDKEAILAHGAGEAVLSVSRLGERRAQGPGGRGGGGGGGAGVPP -> VCVRASEGCCGRVCQVGHACRVCVHERRSWWPQRPGRWLSRRWGFQKARGSPRCRLGV (in isoform 2); 678..888; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
661..674; Gly residues; 706..717; Low complexity
Domain (FT)
31..523; Sema
Region
651..679; Disordered; 695..742; Disordered; 757..888; Disordered
Protein Families
Semaphorin family
Sequence Similarities
Belongs to the semaphorin family.