Protein detail

SEM6B

Semaphorin-6B (Semaphorin-Z) (Sema Z)

Entry name SEM6B	UniProt ID Q9H3T3	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Semaphorin-6B (Semaphorin-Z) (Sema Z)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins

Protein Function (2)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes

Transmembrane

604..624; Helical

Transmembrane Count

Ensembl

ENSG00000167680

Entrez Gene Symbol

SEMA6B

Gene Synonym (4)

SEM-SEMA-ZSEMA-VIBSEMANsemaZ

Gene Description

Semaphorin 6B

Chromosome

Position

4542593-4581776

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificAstrocytes

Function & Pathway7

Protein Function (2)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes

Cellular Component

GO:0005886 plasma membrane

Molecular Function (4)

Biological Process (3)

KEGG

hsa04360 Axon guidance

Canonical Pathways (2)

M247 Pid insulin glucose pathway
M232 Pid ecadherin stabilization pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence35

Ligand-Receptor Signaling (34)

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40222457

Sequence, Structure & Domains10

Sequences

Length

888

Mass

95,285

Sequence

MQTPRASPPRPALLLLLLLLGGAHGLFPEEPPPLSVAPRDYLNHYPVFVGSGPGRLTPAEGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVVLAVFSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAFEQDVSGASTSGLGDCTGLLRASLSEDRAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWFVGLRERRELARRKDKEAILAHGAGEAVLSVSRLGERRAQGPGGRGGGGGGGAGVPPEALLAPLMQNGWAKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEPTPDGRLYAARPGRASHGDFPLTPHASPDRRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTHTFNSGEARPGDRHRGCHARPGTDLAHLLPYGGADRTAPPVP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H3T3-1; Sequence=Displayed; Name=2; IsoId=Q9H3T3-3; Sequence=VSP_047625, VSP_047626

Alternative Sequence

620..677; WFVGLRERRELARRKDKEAILAHGAGEAVLSVSRLGERRAQGPGGRGGGGGGGAGVPP -> VCVRASEGCCGRVCQVGHACRVCVHERRSWWPQRPGRWLSRRWGFQKARGSPRCRLGV (in isoform 2); 678..888; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

661..674; Gly residues; 706..717; Low complexity

Domain (FT)

31..523; Sema

Region

651..679; Disordered; 695..742; Disordered; 757..888; Disordered

Protein Families

Semaphorin family

Sequence Similarities

Belongs to the semaphorin family.

Clinical Relevance2

Disease Involvement (2)

EpilepsyNeurodegeneration

Antibody (3)

CAB025157 HPA055778 HPA058523

Supporting Publications1

PMID	Title	Abstract
34265469	Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer.	Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes.