Protein detail
MFSD1
Lysosomal dipeptide transporter MFSD1 (Major facilitator superfamily domain-containing protein 1) (Smooth muscle cell-associated protein 4) (SMAP-4)
Entry name MFSD1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 13 | Transmembrane count 12 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Lysosomal dipeptide transporter MFSD1 (Major facilitator superfamily domain-containing protein 1) (Smooth muscle cell-associated protein 4) (SMAP-4)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
39..59; Helical; 83..103; Helical; 113..133; Helical; 135..155; Helical; 170..191; Helical; 213..233; Helical; 266..286; Helical; 303..323; Helical; 331..351; Helical; 361..381; Helical; 392..412; Helical; 418..438; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
FLJ14153MinervaUG0581B09
Gene Description
Major facilitator superfamily domain containing 1
Chromosome
3
Position
158732198-158829719
Supporting publications (n)
13
EVMP confidence score
0.72
Fluorescence & Localization3
Tissue Specificparathyroid glandCell SpecificBergmann glia
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (2)
Biological Process (3)
Canonical Pathways (2)
- M247 Pid insulin glucose pathway
- M236 Pid delta np63 pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence15
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACTL8ISYNA1MFSD10PGM1RRM1RRM2RRM2BUBCVAMP1 | P0CG48P23763P23921P31350P36871Q14728Q7LG56Q9H568Q9NPH2 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9248 | ||
| ABCE1MFSD1RNASELUBC | P0CG48P61221Q05823Q9H3U5 | 1:1:1:1 | NetworkBlastCompleat | Compleat:HC4681 | ||
| FUBP1MAP2K6MAPK14MAPKAPK3MFSD1RAB10 | P52564P61026Q16539Q16644Q96AE4Q9H3U5 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8426 | ||
| MAPK14MAPKAPK3MFSD1RAB10SNRPG | P61026P62308Q16539Q16644Q9H3U5 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4288 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 34889606 |
Sequence, Structure & Domains10
Sequences
Length
465
Mass
51,209
Sequence
MEEEDEEARALLAGGPDEADRGAPAAPGALPALCDPSRLAHRLLVLLLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFFGGFLIDRVFGIRWGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEALLGSAGHTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVFGLLVDKTGKNIIWVLCAVAATLVSHMMLAFTMWNPWIAMCLLGLSYSLLACALWPMVAFVVPEHQLGTAYGFMQSIQNLGLAIISIIAGMILDSRGYLFLEVFFIACVSLSLLSVVLLYLVNRAQGGNLNYSARQREEIKFSHTE
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9H3U5-1; Sequence=Displayed; Name=2; IsoId=Q9H3U5-2; Sequence=VSP_022537, VSP_022538; Name=3; IsoId=Q9H3U5-3; Sequence=VSP_037579; Name=4; IsoId=Q9H3U5-4; Sequence=VSP_037578; Name=5; IsoId=Q9H3U5-5; Sequence=VSP_047667, VSP_047668; Name=6; IsoId=Q9H3U5-6; Sequence=VSP_047667
Alternative Sequence
1..73; Missing (in isoform 4); 1; M -> MGVALRDLPGRHVSSRSHVTAVLTVFHGRCFLPGFGVVTTFPSPSPAGAM (in isoform 5 and isoform 6); 55..110; GSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFFGGFLIDRVFGIR -> AIFAMIILLPFRLKLDE (in isoform 3); 55..110; GSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFFGGFLIDRVFGIR -> AIFAMIILLPFRLKLNE (in isoform 5); 73..78; DMQVNT -> MGHNHF (in isoform 2); 79..465; Missing (in isoform 2)
Domain & Motif Annotations
Motif
11..12; Dileucine internalization motif
Domain (CC)
The dileucine internalization motif is required for lysosomal localization.
Region
1..23; Disordered
Protein Families
Major facilitator superfamily
Sequence Similarities
Belongs to the major facilitator superfamily.
Clinical Relevance1
Antibody
Supporting Publications13
| PMID | Title | Abstract |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No abstract available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32944193 | Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties. | No abstract available |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No abstract available |
| 34186243 | A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
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