Protein detail

EHD1

EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)

Entry name EHD1	UniProt ID Q9H4M9	EVMP confidence score 0.88
Supporting publications (n) 113	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteinsTransporters

Basic Information

Protein Names

EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsTransporters

Protein Function (2)

Transporters:Transporter channels and pores
Predicted intracellular proteins

Ensembl

ENSG00000110047

Entrez Gene Symbol

EHD1

Gene Synonym (5)

FLJ42622FLJ44618H-PASTHPAST1PAST1

Gene Description

EH domain containing 1

Chromosome

Position

64851642-64888296

Supporting publications (n)

113

EVMP confidence score

0.88

Fluorescence & Localization

Cell SpecificAstrocytes

Function & Pathway

Protein Function (2)

Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component (15)

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Molecular Function (7)

KEGG

hsa04144 Endocytosis

Reactome (2)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence11

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
EHD1	EGFR	P00533	Y	453	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ARL8B CCT6A CCT8 CLTC CYP24A1 EHD1 GFPT2 GK IPO9 MTARC2 PPP2R1A QNG1 RPN1 SLC25A11 SLC27A4	O94808 P04843 P30153 P32189 P40227 P50990 Q00610 Q02978 Q07973 Q5T6V5 Q6P1M0 Q969Z3 Q96P70 Q9H4M9 Q9NVJ2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4692
ANXA6 EHD1 PAFAH1B2 PAFAH1B3 SMAD1 TBCB	P08133 P68402 Q15102 Q15797 Q99426 Q9H4M9	0:0:0:0:0:0	hu.MAP2
ACTMAP EHD1	Q5BKX5 Q9H4M9	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryWestern blotting	2	37886648 38343172

Sequence, Structure & Domains

Sequences

Length

534

Mass

60,627

Sequence

MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE

3D Structural Models

Turn

523..525

Helix

440..443; 445..454; 464..473; 478..488; 498..512; 528..530

Beta Strand

458..463; 494..497

3D Structure

NMR spectroscopy (5)

Domain & Motif Annotations

Coiled Coil

198..227

Domain (CC)

The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.

Domain (FT)

55..286; Dynamin-type G; 444..532; EH; 476..511; EF-hand

Region

65..72; G1 motif; 91..92; G2 motif; 153..156; G3 motif; 219..222; G4 motif; 243; G5 motif

Protein Families (3)

TRAFAC class dynamin-like GTPase superfamily
Dynamin/Fzo/YdjA family
EHD subfamily

Sequence Similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.

Clinical Relevance

Antibody (4)

HPA049890 HPA049986 HPA066751 HPA067747

Interaction Protein (5)

ENSG00000013016ENSG00000099940ENSG00000100139ENSG00000131381ENSG00000185722

Interaction Count

Interaction Dataset (2)

intact_biogridintact_biogrid_bioplex

Supporting Publications113

PMID	Title	Related sentences
10451508	Simultaneous analysis of the cyan, yellow and green fluorescent proteins by flow cytometry using single-laser excitation at 458 nm.	No related sentences available
20224111	Proteomics analysis of bladder cancer exosomes.	No related sentences available
21362503	Protein profile of exosomes from trabecular meshwork cells.	Several cell-specific proteins in TM exosomes were identified including myocilin, emilin-1 and neuropilin-1. Taken together, TM exosomes have a characteristic exosome protein profile plus contain unique proteins, including the glaucoma-causing protein, myocilin; suggesting a role for exosomes in the control of intraocular pressure.
22329422	Quantitative proteome profiling of normal human circulating microparticles.	No related sentences available
22418980	A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.	No related sentences available
22867456	[object Object]	No related sentences available
23376485	Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.	No related sentences available
2353145	[The Cronkhite-Canada syndrome].	No related sentences available
23585444	Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions.	No related sentences available
24069378	Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression.	We found that the large majority of the proteins identified in NB derived exosomes are present in Exocarta database including tetraspanins, fibronectin, heat shock proteins, MVB proteins, cytoskeleton-related proteins, prominin-1 (CD133), basigin (CD147) and B7-H3 (CD276).

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