Protein detail
EHD1
EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)
Entry name EHD1 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 114 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)
Protein Class (3)
Plasma proteinsPredicted intracellular proteinsTransporters
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
FLJ42622FLJ44618H-PASTHPAST1PAST1
Gene Description
EH domain containing 1
Chromosome
11
Position
64851642-64888296
Supporting publications (n)
114
EVMP confidence score
0.88
Fluorescence & Localization2
Cell SpecificAstrocytes
Function & Pathway6
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component (15)
- GO:0005737 cytoplasm
- GO:0005769 early endosome
- GO:0005811 lipid droplet
- GO:0005886 plasma membrane
- GO:0010008 endosome membrane
- GO:0016020 membrane
- GO:0020018 ciliary pocket membrane
- GO:0030139 endocytic vesicle
- GO:0031095 platelet dense tubular network membrane
- GO:0031901 early endosome membrane
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Molecular Function (7)
Reactome (2)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence11
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EHD1 | EGFR | P00533 | Y | 453 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARL8BCCT6ACCT8CLTCCYP24A1EHD1GFPT2GKIPO9MTARC2PPP2R1AQNG1RPN1SLC25A11SLC27A4 | O94808P04843P30153P32189P40227P50990Q00610Q02978Q07973Q5T6V5Q6P1M0Q969Z3Q96P70Q9H4M9Q9NVJ2 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4692 | ||
| ANXA6EHD1PAFAH1B2PAFAH1B3SMAD1TBCB | P08133P68402Q15102Q15797Q99426Q9H4M9 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ACTMAPEHD1 | Q5BKX5Q9H4M9 | 0:0 | hu.MAP |
Sequence, Structure & Domains13
Sequences
Length
534
Mass
60,627
Sequence
MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
3D Structural Models
Turn
523..525
Helix
440..443; 445..454; 464..473; 478..488; 498..512; 528..530
Beta Strand
458..463; 494..497
3D Structure
NMR spectroscopy (5)
Domain & Motif Annotations
Coiled Coil
198..227
Domain (CC)
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Domain (FT)
55..286; Dynamin-type G; 444..532; EH; 476..511; EF-hand
Region
65..72; G1 motif; 91..92; G2 motif; 153..156; G3 motif; 219..222; G4 motif; 243; G5 motif
Protein Families (3)
- TRAFAC class dynamin-like GTPase superfamily
- Dynamin/Fzo/YdjA family
- EHD subfamily
Sequence Similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
Clinical Relevance4
Supporting Publications113
| PMID | Title | Abstract |
|---|---|---|
| 24700864 | Human urinary exosomes as innate immune effectors. | No abstract available |
| 24733759 | The overexpression of a single oncogene (ERBB2/HER2) alters the proteomic landscape of extracellular vesicles. | However, despite its remarkable importance in oncology, the consequences of HER2 amplification over the extracellular vesicles (EVs) content have not yet been investigated. |
| 25471207 | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | No abstract available |
| 25844599 | Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. | No abstract available |
| 25950383 | Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines. | No abstract available |
| 26538482 | Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles. | No abstract available |
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No abstract available |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No abstract available |
| 26884841 | Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis. | No abstract available |
| 27312428 | A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer. | No abstract available |