Protein detail
EHD1
EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)
Entry name EHD1 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 114 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin)
Protein Class (3)
Plasma proteinsPredicted intracellular proteinsTransporters
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
FLJ42622FLJ44618H-PASTHPAST1PAST1
Gene Description
EH domain containing 1
Chromosome
11
Position
64851642-64888296
Supporting publications (n)
114
EVMP confidence score
0.88
Fluorescence & Localization2
Cell SpecificAstrocytes
Function & Pathway6
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component (15)
- GO:0005737 cytoplasm
- GO:0005769 early endosome
- GO:0005811 lipid droplet
- GO:0005886 plasma membrane
- GO:0010008 endosome membrane
- GO:0016020 membrane
- GO:0020018 ciliary pocket membrane
- GO:0030139 endocytic vesicle
- GO:0031095 platelet dense tubular network membrane
- GO:0031901 early endosome membrane
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Molecular Function (7)
Reactome (2)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence11
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EHD1 | EGFR | P00533 | Y | 453 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARL8BCCT6ACCT8CLTCCYP24A1EHD1GFPT2GKIPO9MTARC2PPP2R1AQNG1RPN1SLC25A11SLC27A4 | O94808P04843P30153P32189P40227P50990Q00610Q02978Q07973Q5T6V5Q6P1M0Q969Z3Q96P70Q9H4M9Q9NVJ2 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4692 | ||
| ANXA6EHD1PAFAH1B2PAFAH1B3SMAD1TBCB | P08133P68402Q15102Q15797Q99426Q9H4M9 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ACTMAPEHD1 | Q5BKX5Q9H4M9 | 0:0 | hu.MAP |
Sequence, Structure & Domains13
Sequences
Length
534
Mass
60,627
Sequence
MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
3D Structural Models
Turn
523..525
Helix
440..443; 445..454; 464..473; 478..488; 498..512; 528..530
Beta Strand
458..463; 494..497
3D Structure
NMR spectroscopy (5)
Domain & Motif Annotations
Coiled Coil
198..227
Domain (CC)
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Domain (FT)
55..286; Dynamin-type G; 444..532; EH; 476..511; EF-hand
Region
65..72; G1 motif; 91..92; G2 motif; 153..156; G3 motif; 219..222; G4 motif; 243; G5 motif
Protein Families (3)
- TRAFAC class dynamin-like GTPase superfamily
- Dynamin/Fzo/YdjA family
- EHD subfamily
Sequence Similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
Clinical Relevance4
Supporting Publications113
| PMID | Title | Abstract |
|---|---|---|
| 31065972 | Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers. | No abstract available |
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No abstract available |
| 31366407 | Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 31685984 | Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. | Proteomic analysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated in exosomes from brain metastatic but not lung or bone metastatic cells. |
| 31694344 | Proteomic Analysis of Urinary Extracellular Vesicles Reveals a Role for the Complement System in Medullary Sponge Kidney Disease. | No abstract available |
| 32295833 | Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. | Notably, mTau exosomes (not control exosomes) contain ANP32A (also known as I1PP2A), an endogenous inhibitor of the PP2A phosphatase which regulates the phosphorylation state of p-Tau. |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 32927759 | Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease. | No abstract available |
| 33017416 | Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers. | No abstract available |