Protein detail
ANTR1
Anthrax toxin receptor 1 (Tumor endothelial marker 8)
Protein symbol ANTR1 | UniProt ID | EVMP score 0.25 |
Frequency 4 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Anthrax toxin receptor 1 (Tumor endothelial marker 8)
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
Transmembrane
322..342; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
4
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M26 Pid nfkappab atypical pathway
- M17200 Sa b cell receptor complexes
- M63 Pid avb3 opn pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
564
Mass
62,789
Sequence
MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV
Alternative Products
Event=Alternative splicing; Named isoforms=6; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9H6X2-1; Sequence=Displayed; Name=2; IsoId=Q9H6X2-2; Sequence=VSP_000444, VSP_000445; Name=3; IsoId=Q9H6X2-3; Sequence=VSP_000446, VSP_000447; Name=4; IsoId=Q9H6X2-4; Sequence=VSP_000448, VSP_000449; Name=5; Synonyms=V4; IsoId=Q9H6X2-5; Sequence=VSP_047865; Name=6; Synonyms=V5; IsoId=Q9H6X2-6; Sequence=VSP_047863, VSP_047864
Alternative Sequence
268..297; NEKPFSVEDTYLLCPAPILKEVGMKAALQV -> SKSLQSPWVSSTSGFKEGNSHPCLPARPHT (in isoform 3); 298..564; Missing (in isoform 3); 315..358; THCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPP -> FHPSPSSPGSTSQQGTSSLPPSSKAFCLEPKVPALGSLRNFRRC (in isoform 6); 319..333; DGSILAIALLILFLL -> LHKIASGPTTAACME (in isoform 4); 334..564; Missing (in isoform 4); 359..564; Missing (in isoform 6); 365..368; EDDD -> NKIK (in isoform 2); 369..564; Missing (in isoform 2); 522..557; Missing (in isoform 5)
3D Structural Models
Turn
189..191
Helix
53..58; 59..72; 99..110; 120..135; 155..170; 185..188; 195..197; 201..217
Beta Strand
40..50; 78..96; 141..149; 173..179; 192..194; 198..200
3D Structure
Electron microscopy (4); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
402..422; Basic and acidic residues; 505..564; Pro residues
Domain (FT)
44..215; VWFA
Region
154..160; Interaction with PA; 356..375; Disordered; 402..444; Disordered; 493..564; Disordered
Protein Families
ATR family
Sequence Similarities
Belongs to the ATR family.
Clinical Relevance
Interaction Protein
ENSG00000100652
Interaction Count
1
Interaction Dataset
biogrid_bioplex