EV MemProt Atlas

Basic Information

Protein Names

Anthrax toxin receptor 1 (Tumor endothelial marker 8)

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Vascular diseases
Predicted intracellular proteins

Transmembrane

322..342; Helical

Transmembrane Count

1

Ensembl

ENSG00000169604

Entrez Gene Symbol

ANTXR1

Frequency

4

EVMP Score

0.25

Fluorescence & Localization

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Vascular diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04621 NOD-like receptor signaling pathway

Reactome

Canonical Pathways

M26 Pid nfkappab atypical pathway
M17200 Sa b cell receptor complexes
M63 Pid avb3 opn pathway

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANTXR1 B4GALNT4 DNAJC12 INSL5 TPH1	P17752 Q76KP1 Q9H6X2 Q9UKB3 Q9Y5Q6	0:0:0:0:0	hu.MAP2
ANTXR1 DNAJC12 TPH1	P17752 Q9H6X2 Q9UKB3	0:0:0	hu.MAP2
ANTXR1 B4GALNT4	Q76KP1 Q9H6X2	0:0	hu.MAP
ANTXR1	Q9H6X2	6	PDB	PDB:3n2n

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass Spectrometry	2	38113368 38207106

Sequence, Structure & Domains

Sequences

Length

564

Mass

62,789

Sequence

MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV

Alternative Products

Event=Alternative splicing; Named isoforms=6; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9H6X2-1; Sequence=Displayed; Name=2; IsoId=Q9H6X2-2; Sequence=VSP_000444, VSP_000445; Name=3; IsoId=Q9H6X2-3; Sequence=VSP_000446, VSP_000447; Name=4; IsoId=Q9H6X2-4; Sequence=VSP_000448, VSP_000449; Name=5; Synonyms=V4; IsoId=Q9H6X2-5; Sequence=VSP_047865; Name=6; Synonyms=V5; IsoId=Q9H6X2-6; Sequence=VSP_047863, VSP_047864

Alternative Sequence

268..297; NEKPFSVEDTYLLCPAPILKEVGMKAALQV -> SKSLQSPWVSSTSGFKEGNSHPCLPARPHT (in isoform 3); 298..564; Missing (in isoform 3); 315..358; THCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPP -> FHPSPSSPGSTSQQGTSSLPPSSKAFCLEPKVPALGSLRNFRRC (in isoform 6); 319..333; DGSILAIALLILFLL -> LHKIASGPTTAACME (in isoform 4); 334..564; Missing (in isoform 4); 359..564; Missing (in isoform 6); 365..368; EDDD -> NKIK (in isoform 2); 369..564; Missing (in isoform 2); 522..557; Missing (in isoform 5)

3D Structural Models

Turn

189..191

Helix

53..58; 59..72; 99..110; 120..135; 155..170; 185..188; 195..197; 201..217

Beta Strand

40..50; 78..96; 141..149; 173..179; 192..194; 198..200

3D Structure

Electron microscopy (4); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

402..422; Basic and acidic residues; 505..564; Pro residues

Domain (FT)

44..215; VWFA

Region

154..160; Interaction with PA; 356..375; Disordered; 402..444; Disordered; 493..564; Disordered

Protein Families

ATR family

Sequence Similarities

Belongs to the ATR family.

Clinical Relevance

Interaction Protein

ENSG00000100652

Interaction Count

1

Interaction Dataset

biogrid_bioplex

Protein symbol ANTR1	UniProt ID Q9H6X2	EVMP score 0.25
Frequency 4	Transmembrane count 1	Protein classification

ANTR1