Protein detail

SYNCI

Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)

Entry name SYNCI	UniProt ID Q9H7C4	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000162520

Entrez Gene Symbol

SYNC

Gene Synonym (2)

SYNC1SYNCOILIN

Gene Description

Syncoilin, intermediate filament protein

Chromosome

Position

32679906-32703596

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificAstrocytes

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence38

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (33)

33 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
DES SYNC VIM	P08670 P17661 Q9H7C4	0:0:0	hu.MAP2
PRPH SYNC	P41219 Q9H7C4	0:0	hu.MAP2
KRT23 SYNC	Q9C075 Q9H7C4	0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometryWestern blotting	0

Sequence, Structure & Domains10

Sequences

Length

482

Mass

55,299

Sequence

MASPEPRRGGDGAAQAARKTRVEANSPLPKNSGSLNEAEALNPEVTLSSEGSLNLEDILYLEDTGDLDETLYVQETEKAEEALYIEEAMQPDEALHVEEPGNPEETVCVEETTEPDRIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSNPEESLRAEQSPSMEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRLVKQKLFKVTKECVAYQYQLECRQQDVAQFADFREVLTTRATQLSEELAQLRDAYQKQKEQLRQQLEAPPSQRDGHFLQESRRLSAQFENLMAESRQDLEEEYEPQFLRLLERKEAGTKALQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEERQRQLRNGVQLQQQKNKEMEQLRLSLAEELSTYKAMLLPKSLEQADAPTSQAGGMETQSQGAV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H7C4-1; Sequence=Displayed; Name=2; IsoId=Q9H7C4-2; Sequence=VSP_039404

Alternative Sequence

454..482; AMLLPKSLEQADAPTSQAGGMETQSQGAV -> GCLEIYGQICNPETAKNFLAKDH (in isoform 2)

Domain & Motif Annotations

Compositional Bias

1..10; Basic and acidic residues; 144..156; Basic and acidic residues; 466..482; Polar residues

Domain (FT)

168..463; IF rod

Region

1..161; Head; 1..42; Disordered; 144..165; Disordered; 170..204; Coil 1A; 205..231; Linker 1; 232..309; Coil 1b; 310..349; Linker 2; 350..458; Coil 2; 459..482; Tail; 460..482; Disordered

Protein Families

Intermediate filament family

Sequence Similarities

Belongs to the intermediate filament family.

Clinical Relevance4

Antibody (2)

HPA028311 HPA063549

Interaction Protein

ENSG00000026025

Interaction Count

Interaction Dataset

intact_biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
29045505	Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.	Proteomic analysis of the exosome 'surfaceome' revealed multiple PDAC-specific biomarker candidates: CLDN4, EPCAM, CD151, LGALS3BP, HIST2H2BE, and HIST2H2BF. Droplet digital PCR was used on 74 patients (136 total exosome samples) to determine baseline KRAS mutation call rates while patients were on therapy. KRAS mutations in total exosomes were detected in 44.1% of patients undergoing active therapy compared with 73.0% following exosome capture using the selected biomarkers.