Protein detail
NMUR1
Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3)
Entry name NMUR1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3)
Protein Class (3)
G-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
66..86; Helical; Name=1; 98..118; Helical; Name=2; 139..161; Helical; Name=3; 182..202; Helical; Name=4; 236..256; Helical; Name=5; 295..315; Helical; Name=6; 339..359; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
FM-3GPC-RGPR66NMU1R
Gene Description
Neuromedin U receptor 1
Chromosome
2
Position
231523187-231530445
Supporting publications (n)
3
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function (2)
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
Reactome (6)
Canonical Pathways
M20 Pid p38 mkk3 6pathway
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence58
Ligand-Receptor Signaling (54)
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Almen2009 | Yes | Yes | |||
| rhodopsin | receptor | Almen2009 | Yes | Yes | |||
| gpcr | receptor | UniProt_keyword | Yes | Yes | |||
| seven_transmembrane_7tm | receptor | HPMR | Yes | Yes | |||
| 7tm_a | receptor | HPMR | Yes | Yes | |||
| neuromedin_u_neurotensin_ghrelin_thyrotropin_releasing_7tm_a | receptor | HPMR | Yes | Yes | |||
| rhodopsin | receptor | Surfaceome | Yes | Yes | |||
| gpcr | receptor | Surfaceome | Yes | Yes | |||
| class_a_rhodopsin | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_peptide | receptor | GPCRdb | Yes | Yes |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NMS | Q5H8A3 | NMUR1 | Q9HB89 | Yes | Yes | iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | CellTalkDB:15635449HPRD:15635449HINT:15635449Cellinker:15635449CellChatDB:29288685HINT:35440625scConnect:15635449LRdb:15635449connectomeDB2020:15635449Cellinker:29288685SIGNOR:15635449Guide2Pharma:15635449 | |
| NMUR1 | Q9HB89 | GNA14 | O95837 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| NMUR1 | Q9HB89 | GNAQ | P50148 | Yes | Yes | SIGNOR | SIGNOR:31160049 |
Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains
Sequences
Length
426
Mass
47,351
Sequence
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS
3D Structural Models
Turn
357..359
Helix
61..87; 89..91; 94..122; 130..159; 160..162; 167..171; 175..197; 225..239; 241..259; 293..322; 331..356; 361..364
Beta Strand
200..202; 219..223
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 24393738 | Oxalate content of foods and its effect on humans. | No related sentences available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |