Protein detail

NMUR1

Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3)

Entry name NMUR1	UniProt ID Q9HB89	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3)

Protein Class (3)

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

66..86; Helical; Name=1; 98..118; Helical; Name=2; 139..161; Helical; Name=3; 182..202; Helical; Name=4; 236..256; Helical; Name=5; 295..315; Helical; Name=6; 339..359; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000171596

Entrez Gene Symbol

NMUR1

Gene Synonym (4)

FM-3GPC-RGPR66NMU1R

Gene Description

Neuromedin U receptor 1

Chromosome

Position

231523187-231530445

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Cell SpecificEsophageal apical cells

Function & Pathway8

Protein Function (2)

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Reactome (6)

Canonical Pathways

M20 Pid p38 mkk3 6pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence58

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
class_a_rhodopsin_peptide_neuromedin_u	receptor	GPCRdb	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NMS	Q5H8A3	NMUR1	Q9HB89	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	CellTalkDB:15635449 HPRD:15635449 HINT:15635449 Cellinker:15635449 CellChatDB:29288685 HINT:35440625 scConnect:15635449 LRdb:15635449 connectomeDB2020:15635449 Cellinker:29288685 SIGNOR:15635449 Guide2Pharma:15635449
NMUR1	Q9HB89	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
NMUR1	Q9HB89	GNAQ	P50148	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	11	34889606 39940785 32795414 23161513 30608700 37926697 37686366 40098346 38698420 40311616 41315767

Sequence, Structure & Domains9

Sequences

Length

426

Mass

47,351

Sequence

MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS

3D Structural Models

Turn

357..359

Helix

61..87; 89..91; 94..122; 130..159; 160..162; 167..171; 175..197; 225..239; 241..259; 293..322; 331..356; 361..364

Beta Strand

200..202; 219..223

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance2

Drugs (14)

[125I]NEUROMEDIN U-8 (PIG)NEUROMEDIN U-8 CPN-267 NM4-C16 HAS-NMU NEUROMEDIN U-23 PEG40-NMU NEUROMEDIN U-25 [125I]NEUROMEDIN U-25 (HUMAN)[125I]NEUROMEDIN U-23 (RAT)CPN-223 NEUROMEDIN S-33 COMPOUND 5D [PMID: 25815150]COMPOUND 8D [PMID: 24999562]

Antibody

HPA027895

Supporting Publications3

PMID	Title	Abstract
24393738	Oxalate content of foods and its effect on humans.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available