Protein detail

CRLF2

Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor)

Entry name CRLF2	UniProt ID Q9HC73	EVMP confidence score 0.38
Supporting publications (n) 5	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor)

Protein Function (2)

Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes

Transmembrane

232..252; Helical

Transmembrane Count

Ensembl

ENSG00000205755

Entrez Gene Symbol

CRLF2

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function (2)

Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence50

Ligand-Receptor Signaling (46)

46 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	UniProt_keyword	No	No	Yes	Yes	No
secreted	secreted	UniProt_location	No	No	Yes	Yes	No
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No
ligand	ligand	CellPhoneDB	Yes	No	Yes	Yes	No
ligand	ligand	OmniPath	Yes	No	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	Yes	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TSLP	Q969D9	CRLF2	Q9HC73	Yes	Yes	No	Guide2PharmaKirouac2010NetPathSIGNORReactome_SignaLink3connectomeDB2020HPRDHINTSignaLink3InnateDBWangCellCall	SIGNOR:11418668 SignaLink3:18988627 connectomeDB2020:22915648 SignaLink3:10570284 NetPath:10881176 NetPath:10974032 HINT:28368013 SignaLink3:11418668 SignaLink3:29145629 SignaLink3:23331499 HPRD:11418668 connectomeDB2020:26198769 InnateDB:11418668
CRLF2	Q9HC73	JAK2	O60674	Yes	Yes	No	WangHPRDNetPathSignaLink3	SignaLink3:18988627 HPRD:10872831 SignaLink3:23331499 NetPath:10872831 SignaLink3:10872831
IL7RA	P16871	CRLF2	Q9HC73	Yes	Yes	No	NetPathHPRDHINTSignaLink3Wang	NetPath:10881176 HINT:28368013 SignaLink3:23331499 HPRD:11418668 SignaLink3:10974032

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	35029059

Sequence, Structure & Domains16

Sequences

Length

371

Mass

42,013

Sequence

MGRLVLLWGAAVFLLGGWMALGQGGAAEGVQIQIIYFNLETVQVTWNASKYSRTNLTFHYRFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNGTHPVFTASRWMVYYLKPSSPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEWQSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFILISSLAILLMVSLLLLSLWKLWRVKKFLIPSVPDPKSIFPGLFEIHQGNFQEWITDTQNVAHLHKMAGAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEKEASGGSLQLPHQPLQGGDVVTIGGFTFVMNDRSYVAL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HC73-1; Sequence=Displayed; Name=2; IsoId=Q9HC73-2; Sequence=VSP_008786, VSP_008787; Name=3; IsoId=Q9HC73-3; Sequence=VSP_057463

Alternative Sequence

1..112; Missing (in isoform 3); 162..233; SKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFI -> TQSRSVTQAGVQWCDLCLLQPSPPRFKRFSCLSLPSSWDYRHPPPRLANFCIISRDGVSPCWPGWSRTCDLR (in isoform 2); 234..371; Missing (in isoform 2)

3D Structural Models

Turn

38..40

Helix

49..51; 113..116; 191..194

Beta Strand

31..37; 41..47; 57..63; 72..77; 80..87; 94..101; 104..112; 126..129; 131..137; 145..153; 161..174; 181..189; 207..210; 213..216

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

322..336; Basic and acidic residues

Motif

200..204; WSXWS motif; 261..269; Box 1 motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is important for association with JAKs.

Domain (FT)

118..211; Fibronectin type-III

Region

322..347; Disordered

Protein Families (2)

Type I cytokine receptor family
Type 5 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Clinical Relevance3

Related Diseases

Asthma

Biomarker

Phase 1

Drugs (3)

SIROLIMUS RUXOLITINIB 2-TERT-BUTYL-9-FLUORO-1,6-DIHYDROBENZO[H]IMIDAZO[4,5-F]ISOQUINOLIN-7-ONE

Supporting Publications5

PMID	Title	Abstract
33936570	Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available