Protein detail
CRLF2
Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor)
Entry name CRLF2 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 5 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor)
Protein Function (2)
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Cancer-related genes
Transmembrane
232..252; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
5
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (2)
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Cancer-related genes
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence50
Ligand-Receptor Signaling (46)
46 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellCall | Yes | Yes | Yes | ||
| receptor | receptor | CellCellInteractions | Yes | Yes | Yes | ||
| transmembrane | transmembrane_predicted | Phobius | Yes | Yes | |||
| transmembrane_phobius | transmembrane_predicted | Almen2009 | Yes | Yes | |||
| transmembrane_sosui | transmembrane_predicted | Almen2009 | Yes | Yes | |||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | Yes | Yes |
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Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TSLP | Q969D9 | CRLF2 | Q9HC73 | Yes | Yes | Guide2PharmaKirouac2010NetPathSIGNORReactome_SignaLink3connectomeDB2020HPRDHINTSignaLink3InnateDBWangCellCall | SIGNOR:11418668SignaLink3:18988627connectomeDB2020:22915648SignaLink3:10570284NetPath:10881176NetPath:10974032HINT:28368013SignaLink3:11418668SignaLink3:29145629SignaLink3:23331499HPRD:11418668connectomeDB2020:26198769InnateDB:11418668 | |
| CRLF2 | Q9HC73 | JAK2 | O60674 | Yes | Yes | WangHPRDNetPathSignaLink3 | SignaLink3:18988627HPRD:10872831SignaLink3:23331499NetPath:10872831SignaLink3:10872831 | |
| IL7RA | P16871 | CRLF2 | Q9HC73 | Yes | Yes | NetPathHPRDHINTSignaLink3Wang | NetPath:10881176HINT:28368013SignaLink3:23331499HPRD:11418668SignaLink3:10974032 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 35029059 |
Sequence, Structure & Domains
Sequences
Length
371
Mass
42,013
Sequence
MGRLVLLWGAAVFLLGGWMALGQGGAAEGVQIQIIYFNLETVQVTWNASKYSRTNLTFHYRFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNGTHPVFTASRWMVYYLKPSSPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEWQSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFILISSLAILLMVSLLLLSLWKLWRVKKFLIPSVPDPKSIFPGLFEIHQGNFQEWITDTQNVAHLHKMAGAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEKEASGGSLQLPHQPLQGGDVVTIGGFTFVMNDRSYVAL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HC73-1; Sequence=Displayed; Name=2; IsoId=Q9HC73-2; Sequence=VSP_008786, VSP_008787; Name=3; IsoId=Q9HC73-3; Sequence=VSP_057463
Alternative Sequence
1..112; Missing (in isoform 3); 162..233; SKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKFI -> TQSRSVTQAGVQWCDLCLLQPSPPRFKRFSCLSLPSSWDYRHPPPRLANFCIISRDGVSPCWPGWSRTCDLR (in isoform 2); 234..371; Missing (in isoform 2)
3D Structural Models
Turn
38..40
Helix
49..51; 113..116; 191..194
Beta Strand
31..37; 41..47; 57..63; 72..77; 80..87; 94..101; 104..112; 126..129; 131..137; 145..153; 161..174; 181..189; 207..210; 213..216
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
322..336; Basic and acidic residues
Motif
200..204; WSXWS motif; 261..269; Box 1 motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is important for association with JAKs.
Domain (FT)
118..211; Fibronectin type-III
Region
322..347; Disordered
Protein Families (2)
- Type I cytokine receptor family
- Type 5 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Clinical Relevance
Related Diseases
Biomarker
Phase 1
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 33936570 | Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |