Protein detail
E41L5
Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)
Entry name E41L5 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 20 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (7)
BE37FLJ12957KIAA1548LULULULU1YMO1YRT
Gene Description
Erythrocyte membrane protein band 4.1 like 5
Chromosome
2
Position
120013077-120179119
Supporting publications (n)
20
EVMP confidence score
0.72
Fluorescence & Localization
Tissue SpecifictongueCell SpecificMyonuclei
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence9
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| ferm_domain | intracellular_intercellular_related | HGNC | Yes | ||||
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Sequence, Structure & Domains
Sequences
Length
733
Mass
81,856
Sequence
MLSFFRRTLGRRSMRKHAEKERLREAQRAATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKACATKPEELSVHNNVSTQSNGSQQAWGMRSALPVSPSISSAPVPVEIENLPQSPGTDQHDRKCIPLNIDLLNSPDLLEATIGDVIGASDTMETSQALNDVNVATRLPGLGEPEVEYETLKDTSEKLKQLEMENSPLLSPRSNIDVNINSQEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPLPKESLETLMLITPADSGSVLKEATDELDALLASLTENLIDHTVAPQVSSTSMITPRWIVPQSGAMSNGLAGCEMLLTGKEGHGNKDGISLISPPAPFLVDAVTSSGPILAEEAVLKQKCLLTTEL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9HCM4-1; Sequence=Displayed; Name=2; IsoId=Q9HCM4-2; Sequence=VSP_033034, VSP_033035; Name=3; IsoId=Q9HCM4-3; Sequence=VSP_033036; Name=4; IsoId=Q9HCM4-4; Sequence=VSP_033037, VSP_033038
Alternative Sequence
446..505; CIPLNIDLLNSPDLLEATIGDVIGASDTMETSQALNDVNVATRLPGLGEPEVEYETLKDT -> WLSAASDCCQRGGNQWNTRALPPPQTAHRNYTDFVHEHNVKNAGIRHDVHFPGHTAMTEI (in isoform 2); 506..733; Missing (in isoform 2); 668..669; PQ -> P (in isoform 3); 669..687; QSGAMSNGLAGCEMLLTGK -> LWSHFGRRSCPEAEVFTDH (in isoform 4); 688..733; Missing (in isoform 4)
Domain & Motif Annotations
Domain (FT)
43..327; FERM
Region
29..119; Required for interaction with CRB1
Clinical Relevance
Supporting Publications20
| PMID | Title | Related sentences |
|---|---|---|
| 23161513 | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins. |
| 28242843 | Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line. | No related sentences available |
| 30382917 | Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles. | No related sentences available |
| 30608700 | Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs. | No related sentences available |
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No related sentences available |
| 31196968 | Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway. | No related sentences available |
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No related sentences available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No related sentences available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
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