Protein detail
E41L5
Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)
Entry name E41L5 | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 21 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Band 4.1-like protein 5 (Erythrocyte membrane protein band 4.1-like 5)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (7)
BE37FLJ12957KIAA1548LULULULU1YMO1YRT
Gene Description
Erythrocyte membrane protein band 4.1 like 5
Chromosome
2
Position
120013077-120179119
Supporting publications (n)
21
EVMP confidence score
0.88
Fluorescence & Localization2
Tissue SpecifictongueCell SpecificMyonuclei
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence9
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ferm_domain | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Sequence, Structure & Domains7
Sequences
Length
733
Mass
81,856
Sequence
MLSFFRRTLGRRSMRKHAEKERLREAQRAATHIPAAGDSKSIITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKACATKPEELSVHNNVSTQSNGSQQAWGMRSALPVSPSISSAPVPVEIENLPQSPGTDQHDRKCIPLNIDLLNSPDLLEATIGDVIGASDTMETSQALNDVNVATRLPGLGEPEVEYETLKDTSEKLKQLEMENSPLLSPRSNIDVNINSQEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPLPKESLETLMLITPADSGSVLKEATDELDALLASLTENLIDHTVAPQVSSTSMITPRWIVPQSGAMSNGLAGCEMLLTGKEGHGNKDGISLISPPAPFLVDAVTSSGPILAEEAVLKQKCLLTTEL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9HCM4-1; Sequence=Displayed; Name=2; IsoId=Q9HCM4-2; Sequence=VSP_033034, VSP_033035; Name=3; IsoId=Q9HCM4-3; Sequence=VSP_033036; Name=4; IsoId=Q9HCM4-4; Sequence=VSP_033037, VSP_033038
Alternative Sequence
446..505; CIPLNIDLLNSPDLLEATIGDVIGASDTMETSQALNDVNVATRLPGLGEPEVEYETLKDT -> WLSAASDCCQRGGNQWNTRALPPPQTAHRNYTDFVHEHNVKNAGIRHDVHFPGHTAMTEI (in isoform 2); 506..733; Missing (in isoform 2); 668..669; PQ -> P (in isoform 3); 669..687; QSGAMSNGLAGCEMLLTGK -> LWSHFGRRSCPEAEVFTDH (in isoform 4); 688..733; Missing (in isoform 4)
Domain & Motif Annotations
Domain (FT)
43..327; FERM
Region
29..119; Required for interaction with CRB1
Clinical Relevance4
Supporting Publications20
| PMID | Title | Abstract |
|---|---|---|
| 36332889 | A comparative Proteomics Analysis Identified Differentially Expressed Proteins in Pancreatic Cancer-Associated Stellate Cell Small Extracellular Vesicles. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 37926697 | Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |
| 40928027 | Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes. | No abstract available |
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