Protein detail

CD248

Endosialin (Tumor endothelial marker 1) (CD antigen CD248)

Entry name
CD248
UniProt ID
Q9HCU0
EVMP confidence score
0.72
Supporting publications (n)
11
Transmembrane count
1
Protein classification
CD markersPredicted membrane proteins
Basic Information
Protein Names
Endosialin (Tumor endothelial marker 1) (CD antigen CD248)
Protein Class (2)
CD markersPredicted membrane proteins
Protein Function
CD markers
Transmembrane
688..708; Helical
Transmembrane Count
1
Ensembl
ENSG00000174807
Entrez Gene Symbol
CD248
Gene Synonym (2)
CD164L1TEM1
Gene Description
CD248 molecule
Chromosome
11
Position
66314494-66317044
Supporting publications (n)
11
EVMP confidence score
0.72
Fluorescence & Localization
CD248 fluorescence
Tissue SpecifictestisCell SpecificEarly spermatidsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
CD markers
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence44

Ligand-Receptor Signaling (43)

43 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYesYes
ecmecmCellCellInteractionsYesYes
ecmecmOmniPathYesYes
extracellularextracellularHPMRYes
extracellularextracellularDGIdbYes
extracellularextracellularOmniPathYes
intracellularintracellularComPPIYes
intracellularintracellularGO_IntercellYes
intracellularintracellularOmniPathYes
cell_surface_ligandcell_surface_ligandCellPhoneDBYesYes
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]R Sequencing3374274303426546940689422
Sequence, Structure & Domains

Sequences

Length
757
Mass
80,859
Sequence
MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HCU0-1; Sequence=Displayed; Name=2; IsoId=Q9HCU0-2; Sequence=VSP_017087
Alternative Sequence
1..324; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
618..627; Low complexity; 748..757; Polar residues
Domain (FT)
30..156; C-type lectin; 162..232; Sushi; 312..351; EGF-like; calcium-binding
Region
618..662; Disordered; 737..757; Disordered
Clinical Relevance
Related Diseases (5)
Colorectal cancerKaposi sarcomaMelanomaNeuroendocrine carcinomaSarcoma
Biomarker
Phase 2
Drugs (2)
ONTUXIZUMABNULL
Antibody
HPA051856
Supporting Publications11
PMIDTitleRelated sentences
41315767Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma.No related sentences available
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