Protein detail

PTPRH

Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)

Entry name PTPRH	UniProt ID Q9HD43	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)

Protein Function (2)

Enzymes
ENZYME proteins:Hydrolases

Transmembrane

755..775; Helical

Transmembrane Count

Ensembl

ENSG00000080031

Entrez Gene Symbol

PTPRH

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificliverCell SpecificHepatocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway5

Protein Function (2)

Enzymes
ENZYME proteins:Hydrolases

Cellular Component (5)

Molecular Function (4)

Biological Process (3)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence45

Ligand-Receptor Signaling (41)

41 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor_tyrosine_phosphatase	receptor	Almen2009	No	Yes	No	Yes	No
receptor_like_protein_tyrosine_phosphatases_rptps	receptor	HPMR	No	Yes	No	Yes	No
rptpeta	receptor	HPMR	No	Yes	No	Yes	No
receptortypephosphatases	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTPRH	Q9HD43	INSR	P06213	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:10734133 SIGNOR:10734133
PTPRH	Q9HD43	EGFR	P00533	Yes	No	Yes	SIGNOR	SIGNOR:28065597
PTPRH	Q9HD43	GHR	P10912	Yes	No	Yes	Lit-BM-17SIGNORIntAct	Lit-BM-17:12907755 IntAct:12907755 SIGNOR:12907755

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]	2	35029059 32396726

Sequence, Structure & Domains13

Sequences

Length

1,115

Mass

122,353

Sequence

MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HD43-1; Sequence=Displayed; Name=2; IsoId=Q9HD43-2; Sequence=VSP_031318; Name=3; IsoId=Q9HD43-3; Sequence=VSP_054222

Alternative Sequence

84..261; Missing (in isoform 2); 126..303; Missing (in isoform 3)

3D Structural Models

Turn

828..833; 837..840; 857..859; 870..873; 968..971

Helix

802..804; 805..827; 842..847; 897..899; 900..910; 993..1007; 1025..1043; 1048..1058; 1066..1082

Beta Strand

876..880; 888..892; 914..917; 921..923; 940..942; 945..954; 956..967; 972..981; 1012..1014; 1017..1019; 1021..1024; 1044..1046

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (CC)

The extracellular domain mediates homodimerization. One or more cysteines in the extracellular domain is essential for the formation of dimers probably by forming a disulfide bond.; DOMAIN: The cytoplasmic domain mediates the interaction with LCK.

Domain (FT)

32..121; Fibronectin type-III 1; 122..209; Fibronectin type-III 2; 210..299; Fibronectin type-III 3; 300..387; Fibronectin type-III 4; 388..477; Fibronectin type-III 5; 478..563; Fibronectin type-III 6; 564..666; Fibronectin type-III 7; 665..749; Fibronectin type-III 8; 820..1079; Tyrosine-protein phosphatase

Protein Families (2)

Protein-tyrosine phosphatase family
Receptor class 3 subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

Clinical Relevance3

Interaction Protein (2)

ENSG00000112964ENSG00000146648

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available