Protein detail
PTPRH
Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
Entry name PTPRH | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
755..775; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificliverCell SpecificHepatocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRH | Q9HD43 | INSR | P06213 | Yes | No | Yes | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:10734133SIGNOR:10734133 |
| PTPRH | Q9HD43 | EGFR | P00533 | Yes | No | Yes | SIGNOR | SIGNOR:28065597 |
| PTPRH | Q9HD43 | GHR | P10912 | Yes | No | Yes | Lit-BM-17SIGNORIntAct | Lit-BM-17:12907755IntAct:12907755SIGNOR:12907755 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
1,115
Mass
122,353
Sequence
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLCASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HD43-1; Sequence=Displayed; Name=2; IsoId=Q9HD43-2; Sequence=VSP_031318; Name=3; IsoId=Q9HD43-3; Sequence=VSP_054222
Alternative Sequence
84..261; Missing (in isoform 2); 126..303; Missing (in isoform 3)
3D Structural Models
Turn
828..833; 837..840; 857..859; 870..873; 968..971
Helix
802..804; 805..827; 842..847; 897..899; 900..910; 993..1007; 1025..1043; 1048..1058; 1066..1082
Beta Strand
876..880; 888..892; 914..917; 921..923; 940..942; 945..954; 956..967; 972..981; 1012..1014; 1017..1019; 1021..1024; 1044..1046
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
The extracellular domain mediates homodimerization. One or more cysteines in the extracellular domain is essential for the formation of dimers probably by forming a disulfide bond.; DOMAIN: The cytoplasmic domain mediates the interaction with LCK.
Domain (FT)
32..121; Fibronectin type-III 1; 122..209; Fibronectin type-III 2; 210..299; Fibronectin type-III 3; 300..387; Fibronectin type-III 4; 388..477; Fibronectin type-III 5; 478..563; Fibronectin type-III 6; 564..666; Fibronectin type-III 7; 665..749; Fibronectin type-III 8; 820..1079; Tyrosine-protein phosphatase
Protein Families
- Protein-tyrosine phosphatase family
- Receptor class 3 subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Clinical Relevance
Interaction Protein
ENSG00000112964ENSG00000146648
Interaction Count
2
Interaction Dataset
intact_biogrid