EV MemProt Atlas

Basic Information

Protein Names

Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000102981

Entrez Gene Symbol

PARD6A

Gene Synonym

PAR-6PAR-6APAR6alphaTAX40TIP-40

Gene Description

Par-6 family cell polarity regulator alpha

Chromosome

16

Position

67660946-67662774

Frequency

5

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M106 Pid hnf3b pathway
M255 Pid hif1 tfpathway
M66 Pid myc activ pathway

Mediation Categories

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

8 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PARD6A	PRKCI	P41743	S	345	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
PARD6A	PRKCZ	Q05513	S	345	phosphorylation	PhosphoSite
PARD6A	TGFBR2	P37173	S	345	phosphorylation	SIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:25756394 ProtMapper:24231509 ProtMapper:15761148 ProtMapper:19114990 ProtMapper:23249950
PARD6A	TGFB1	P01137	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFBR1	P36897	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFBI	Q15582	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFA	P01135	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFB3	P10600	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394

Ligand-Receptor Signaling

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	Ramilowski_location	Yes	Yes	No	No	No

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Regulatory Interaction Network

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TGFR2	P37173	PAR6A	Q9NPB6	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperSPIKESPIKE_LC	ProtMapper:25756394 SIGNOR:23249950 ProtMapper:24231509 ProtMapper:15761148 ProtMapper:19114990 SIGNOR:15761148 SPIKE:15761148 ProtMapper:23249950 SPIKE_LC:15761148
PAR6A	Q9NPB6	SMUF1	Q9HCE7	Yes	Yes	No	NetPathSignaLink3BioGRIDSPIKE_LCSPIKE	SignaLink3:21262463 NetPath:15761148 BioGRID:21262463 SignaLink3:19114990 SPIKE:15761148 SignaLink3:23331499 BioGRID:15761148 SPIKE_LC:15761148
TGFR1	P36897	PAR6A	Q9NPB6	Yes	Yes	No	Sparser_ProtMapperNetPathPhosphoPointProtMapperHPRDSignaLink3SPIKE_LCSPIKE	ProtMapper:25756394 NetPath:15761148 HPRD:15761153 SignaLink3:19114990 SPIKE:15761148 SignaLink3:23331499 SPIKE_LC:15761148
DVL2	O14641	PAR6A	Q9NPB6	Yes	Yes	No	HPRDSIGNOR	SIGNOR:23151663 HPRD:19379695
KPCI	P41743	PAR6A	Q9NPB6	Yes	Yes	No	WangiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTHuRIIntActInnateDBSPIKE_LCLit-BM-17PhosphoSite_ProtMapper	HINT:14676191 Lit-BM-17:14676191 Lit-BM-17:17057644 Lit-BM-17:16861740 InnateDB:11260256 HINT:15590654 IntAct:16189514 SPIKE_LC:11257119 IntAct:14676191 IntAct:11257119 HPRD:11260256 IntAct:25416956 Lit-BM-17:12813044 Lit-BM-17:26496610 IntAct:15590654 IntAct:11260256 IntAct:21516116 HINT:17057644 HINT:11257119 HINT:16861740 HINT:11260256 HINT:26496610 HINT:12813044 Lit-BM-17:15590654 SIGNOR:23249950 HPRD:12813044 IntAct:17057644 Lit-BM-17:11257119 Lit-BM-17:11260256 SPIKE_LC:16189514
KPCZ	Q05513	PAR6A	Q9NPB6	Yes	Yes	No	DOMINOWangPhosphoPointSIGNORProtMapperHPRDHINTIntActInnateDBSPIKE_LCLit-BM-17PhosphoSitePhosphoSite_ProtMapper	HINT:14676191 Lit-BM-17:14676191 Lit-BM-17:17057644 InnateDB:11260256 IntAct:16189514 SPIKE_LC:11260256 HINT:25852190 HINT:17350623 HPRD:11260256 Lit-BM-17:12813044 Lit-BM-17:15254234 HPRD:17335965 IntAct:11260256 HINT:17057644 PhosphoSite:23249950 IntAct:17350623 DOMINO:17350623 Lit-BM-17:17350623 HINT:15254234 HINT:11260256 InnateDB:10873802 HINT:33961781 Lit-BM-17:25852190 HINT:12813044 SIGNOR:23249950 HPRD:12813044 HINT:10873802 IntAct:17057644 Lit-BM-17:11260256 SPIKE_LC:16189514
PAR6A	Q9NPB6	KPCA	P17252	Yes	Yes	No	SIGNOR	SIGNOR:22544755

Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PARD6/SMURF1	PARD6A SMURF1	Q9HCE7 Q9NPB6	1:1	SIGNORCompleat	Compleat:HC2660SIGNOR:SIGNOR-C112	15761148
mPar6c-Mlgl-aPKC complex	LLGL1 LLGL2 PARD6A PRKCI	P41743 Q15334 Q6P1M3 Q9NPB6	1:1:1:1	Compleat	Compleat:HC3076	12629547
mPar6c-Mlgl-aPKCz complex	LLGL1 LLGL2 PARD6A PRKCZ	Q05513 Q15334 Q6P1M3 Q9NPB6	1:1:1:1	Compleat	Compleat:HC1252	12629547
	LLGL2 PARD6A PRKCI	P41743 Q6P1M3 Q9NPB6	0:0:0	hu.MAP
	PARD6A PRKCI	P41743 Q9NPB6	1:1	PDB	PDB:1wmh

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	7	38113368 37322475 40189497 33592500 36146834 38207106 37926756

Sequence, Structure & Domains

Sequences

Length

346

Mass

37,388

Sequence

MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPB6-1; Sequence=Displayed; Name=2; IsoId=Q9NPB6-2; Sequence=VSP_007459

Alternative Sequence

96; Missing (in isoform 2)

3D Structural Models

Helix

33..35; 39..49; 74..80

Beta Strand

15..22; 25..32; 58..62; 68..70; 83..86; 88..93

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (CC)

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.; DOMAIN: The PB1 domain mediates interactions with MAP2K5..; DOMAIN: The PDZ domain mediates the interaction with CRB3..

Domain (FT)

15..95; PB1; 133..150; Pseudo-CRIB; 157..250; PDZ

Region

1..116; Interaction with PRKCI and PRKCZ; 126..253; Interaction with PARD3 and CDC42; 257..346; Disordered

Protein Families

PAR6 family

Sequence Similarities

Belongs to the PAR6 family.

Clinical Relevance

Antibody

CAB009733 HPA041551

Interaction Protein

ENSG00000067606ENSG00000070831ENSG00000073350ENSG00000136238ENSG00000148498ENSG00000163558

Interaction Count

6

Interaction Dataset

intact_biogrid

Entry name PAR6A	UniProt ID Q9NPB6	EVMP score 0.38
Frequency 5	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

PAR6A