Protein detail

PAR6A

Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)

Entry name PAR6A	UniProt ID Q9NPB6	EVMP confidence score 0.38
Supporting publications (n) 5	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000102981

Entrez Gene Symbol

PARD6A

Gene Synonym (5)

PAR-6PAR-6APAR6alphaTAX40TIP-40

Gene Description

Par-6 family cell polarity regulator alpha

Chromosome

Position

67660946-67662774

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (11)

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Molecular Function (3)

Biological Process (3)

KEGG (7)

Reactome (16)

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Canonical Pathways (3)

M106 Pid hnf3b pathway
M255 Pid hif1 tfpathway
M66 Pid myc activ pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence35

Enzyme-Mediated Modification (8)

8 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PARD6A	PRKCI	P41743	S	345	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
PARD6A	PRKCZ	Q05513	S	345	phosphorylation	PhosphoSite
PARD6A	TGFBR2	P37173	S	345	phosphorylation	SIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:25756394 ProtMapper:24231509 ProtMapper:15761148 ProtMapper:19114990 ProtMapper:23249950
PARD6A	TGFB1	P01137	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFBR1	P36897	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFBI	Q15582	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFA	P01135	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394
PARD6A	TGFB3	P10600	S	345	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25756394

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network (7)

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TGFR2	P37173	PAR6A	Q9NPB6	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperSPIKESPIKE_LC	ProtMapper:25756394 SIGNOR:23249950 ProtMapper:24231509 ProtMapper:15761148 ProtMapper:19114990 SIGNOR:15761148 SPIKE:15761148 ProtMapper:23249950 SPIKE_LC:15761148
PAR6A	Q9NPB6	SMUF1	Q9HCE7	Yes	Yes	No	NetPathSignaLink3BioGRIDSPIKE_LCSPIKE	SignaLink3:21262463 NetPath:15761148 BioGRID:21262463 SignaLink3:19114990 SPIKE:15761148 SignaLink3:23331499 BioGRID:15761148 SPIKE_LC:15761148
TGFR1	P36897	PAR6A	Q9NPB6	Yes	Yes	No	Sparser_ProtMapperNetPathPhosphoPointProtMapperHPRDSignaLink3SPIKE_LCSPIKE	ProtMapper:25756394 NetPath:15761148 HPRD:15761153 SignaLink3:19114990 SPIKE:15761148 SignaLink3:23331499 SPIKE_LC:15761148
DVL2	O14641	PAR6A	Q9NPB6	Yes	Yes	No	HPRDSIGNOR	SIGNOR:23151663 HPRD:19379695
KPCI	P41743	PAR6A	Q9NPB6	Yes	Yes	No	WangiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTHuRIIntActInnateDBSPIKE_LCLit-BM-17PhosphoSite_ProtMapper	HINT:14676191 Lit-BM-17:14676191 Lit-BM-17:17057644 Lit-BM-17:16861740 InnateDB:11260256 HINT:15590654 IntAct:16189514 SPIKE_LC:11257119 IntAct:14676191 IntAct:11257119 HPRD:11260256 IntAct:25416956 Lit-BM-17:12813044 Lit-BM-17:26496610 IntAct:15590654 IntAct:11260256 IntAct:21516116 HINT:17057644 HINT:11257119 HINT:16861740 HINT:11260256 HINT:26496610 HINT:12813044 Lit-BM-17:15590654 SIGNOR:23249950 HPRD:12813044 IntAct:17057644 Lit-BM-17:11257119 Lit-BM-17:11260256 SPIKE_LC:16189514
KPCZ	Q05513	PAR6A	Q9NPB6	Yes	Yes	No	DOMINOWangPhosphoPointSIGNORProtMapperHPRDHINTIntActInnateDBSPIKE_LCLit-BM-17PhosphoSitePhosphoSite_ProtMapper	HINT:14676191 Lit-BM-17:14676191 Lit-BM-17:17057644 InnateDB:11260256 IntAct:16189514 SPIKE_LC:11260256 HINT:25852190 HINT:17350623 HPRD:11260256 Lit-BM-17:12813044 Lit-BM-17:15254234 HPRD:17335965 IntAct:11260256 HINT:17057644 PhosphoSite:23249950 IntAct:17350623 DOMINO:17350623 Lit-BM-17:17350623 HINT:15254234 HINT:11260256 InnateDB:10873802 HINT:33961781 Lit-BM-17:25852190 HINT:12813044 SIGNOR:23249950 HPRD:12813044 HINT:10873802 IntAct:17057644 Lit-BM-17:11260256 SPIKE_LC:16189514
PAR6A	Q9NPB6	KPCA	P17252	Yes	Yes	No	SIGNOR	SIGNOR:22544755

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PARD6/SMURF1	PARD6A SMURF1	Q9HCE7 Q9NPB6	1:1	SIGNORCompleat	Compleat:HC2660SIGNOR:SIGNOR-C112	15761148
mPar6c-Mlgl-aPKC complex	LLGL1 LLGL2 PARD6A PRKCI	P41743 Q15334 Q6P1M3 Q9NPB6	1:1:1:1	Compleat	Compleat:HC3076	12629547
mPar6c-Mlgl-aPKCz complex	LLGL1 LLGL2 PARD6A PRKCZ	Q05513 Q15334 Q6P1M3 Q9NPB6	1:1:1:1	Compleat	Compleat:HC1252	12629547
	LLGL2 PARD6A PRKCI	P41743 Q6P1M3 Q9NPB6	0:0:0	hu.MAP
	PARD6A PRKCI	P41743 Q9NPB6	1:1	PDB	PDB:1wmh

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	7	38113368 37322475 40189497 33592500 36146834 38207106 37926756

Sequence, Structure & Domains13

Sequences

Length

346

Mass

37,388

Sequence

MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPB6-1; Sequence=Displayed; Name=2; IsoId=Q9NPB6-2; Sequence=VSP_007459

Alternative Sequence

96; Missing (in isoform 2)

3D Structural Models

Helix

33..35; 39..49; 74..80

Beta Strand

15..22; 25..32; 58..62; 68..70; 83..86; 88..93

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (CC)

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.; DOMAIN: The PB1 domain mediates interactions with MAP2K5..; DOMAIN: The PDZ domain mediates the interaction with CRB3..

Domain (FT)

15..95; PB1; 133..150; Pseudo-CRIB; 157..250; PDZ

Region

1..116; Interaction with PRKCI and PRKCZ; 126..253; Interaction with PARD3 and CDC42; 257..346; Disordered

Protein Families

PAR6 family

Sequence Similarities

Belongs to the PAR6 family.

Clinical Relevance4

Antibody (2)

CAB009733 HPA041551

Interaction Protein (6)

ENSG00000067606ENSG00000070831ENSG00000073350ENSG00000136238ENSG00000148498ENSG00000163558

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications5

PMID	Title	Abstract
30071318	Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.	No abstract available
33580265	Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available