Protein detail

SO1B3

Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)

Entry name
SO1B3
UniProt ID
Q9NPD5
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
12
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
  • Disease related genes
  • Transporters:Electrochemical Potential-driven transporters
  • Potential drug targets
Transmembrane
29..48; Helical; Name=1; 68..88; Helical; Name=2; 95..119; Helical; Name=3; 169..197; Helical; Name=4; 217..237; Helical; Name=5; 256..280; Helical; Name=6; 332..353; Helical; Name=7; 374..397; Helical; Name=8; 402..425; Helical; Name=9; 538..560; Helical; Name=10; 570..595; Helical; Name=11; 630..647; Helical; Name=12
Transmembrane Count
12
Ensembl
ENSG00000111700
Entrez Gene Symbol
SLCO1B3
Gene Synonym (3)
OATP1B3OATP8SLC21A8
Gene Description
Solute carrier organic anion transporter family member 1B3
Chromosome
12
Position
20810702-20916911
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificT-cellsSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Protein Function (4)
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
  • Disease related genes
  • Transporters:Electrochemical Potential-driven transporters
  • Potential drug targets
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (2)
Reactome (14)
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Canonical Pathways (3)
  • M185 Pid alk1 pathway
  • M33 Pid glypican 1pathway
  • M53 Pid integrin3 pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence28

Ligand-Receptor Signaling (27)

27 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
extracellularextracellularOmniPath
intracellularintracellularLOCATE
intracellularintracellularOmniPath
transportertransporterSurfaceomeYes
solute_carriertransporterAlmen2009Yes
mfstransporterSurfaceomeYes
slcotransporterSurfaceomeYes
slctransporterSurfaceomeYes
transportertransporterOmniPathYes
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry140089067
Sequence, Structure & Domains

Sequences

Length
702
Mass
77,403
Sequence
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=SLCO1B3-1; IsoId=Q9NPD5-1; Sequence=Displayed; Name=SLCO1B3-2; IsoId=Q9NPD5-2; Sequence=VSP_056615, VSP_056616, VSP_056617; Name=SLCO1B3-SLCO1B7-1; IsoId=F5H094-1; Sequence=External
Alternative Sequence
622..664; GRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERK -> GIVQPELKALAIGFHSMIMRSLGGILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYLGRAFFGLKVALIFPVLVLLTVFIFVVRKKSHGKDTKVLENERQ (in isoform SLCO1B3-2); 676..677; NG -> DS (in isoform SLCO1B3-2); 685..702; GTDSKTCNLDMQDNAAAN -> EEQ (in isoform SLCO1B3-2)

3D Structural Models

Turn
425..427; 437..439
Helix
27..50; 52..59; 63..84; 93..112; 114..117; 171..185; 188..199; 208..216; 218..230; 258..273; 274..276; 325..334; 336..357; 359..367; 371..400; 404..424; 458..461; 484..487; 505..507; 528..560; 565..567; 568..584; 587..597; 618..648
Beta Strand
242..244; 444..447; 473..475; 480..482; 519..522; 599..602; 612..616
3D Structure
Electron microscopy (1)

Domain & Motif Annotations

Domain (CC)
A conserved histidine residue in the third TMD (His-115) may play an essential role in the pH sensitivity of SLCO1B3/OATP1B3-mediated substrate transport.
Domain (FT)
453..508; Kazal-like
Protein Families
Organo anion transporter (TC 2.A.60) family
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Clinical Relevance
Drugs (27)
CARBOPLATINSUNITINIBPRAVASTATIN SODIUM[3H]BSPGLYCYRRHIZIC ACIDISOSILYBIN BMYCOPHENOLATE[3H]ESTRADIOL-17&BETA-GLUCURONIDESILIBININSULFOBROMOPHTHALEINSILIDIANINELTROMBOPAGNULLWARFARINIRINOTECAN HYDROCHLORIDEPACLITAXELSILDENAFIL[3H]CCK-8 (HUMAN, MOUSE, RAT)TELMISARTANVORICONAZOLECYCLOSPORINEGEMFIBROZILMK-8245RIFAMPINDIOSCINRIFAMYCIN SV
Antibody (2)
HPA004943HPA050892
Supporting Publications1
PMIDTitleRelated sentences
38071653Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis.Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis.