Protein detail
SO1B3
Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
Entry name SO1B3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (OATP1B3) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Transmembrane
29..48; Helical; Name=1; 68..88; Helical; Name=2; 95..119; Helical; Name=3; 169..197; Helical; Name=4; 217..237; Helical; Name=5; 256..280; Helical; Name=6; 332..353; Helical; Name=7; 374..397; Helical; Name=8; 402..425; Helical; Name=9; 538..560; Helical; Name=10; 570..595; Helical; Name=11; 630..647; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
OATP1B3OATP8SLC21A8
Gene Description
Solute carrier organic anion transporter family member 1B3
Chromosome
12
Position
20810702-20916911
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificT-cellsSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Disease related genes
- Transporters:Electrochemical Potential-driven transporters
- Potential drug targets
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9754706 atorvastatin adme
- R-hsa-194068 bile acid and bile salt metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-9748784 drug adme
- R-hsa-189483 heme degradation
- R-hsa-556833 metabolism of lipids
- R-hsa-189445 metabolism of porphyrins
- R-hsa-8957322 metabolism of steroids
- R-hsa-879518 organic anion transport by slco transporters
- R-hsa-159418 recycling of bile acids and salts
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M185 Pid alk1 pathway
- M33 Pid glypican 1pathway
- M53 Pid integrin3 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basal_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 40089067 |
Sequence, Structure & Domains
Sequences
Length
702
Mass
77,403
Sequence
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=SLCO1B3-1; IsoId=Q9NPD5-1; Sequence=Displayed; Name=SLCO1B3-2; IsoId=Q9NPD5-2; Sequence=VSP_056615, VSP_056616, VSP_056617; Name=SLCO1B3-SLCO1B7-1; IsoId=F5H094-1; Sequence=External
Alternative Sequence
622..664; GRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERK -> GIVQPELKALAIGFHSMIMRSLGGILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYLGRAFFGLKVALIFPVLVLLTVFIFVVRKKSHGKDTKVLENERQ (in isoform SLCO1B3-2); 676..677; NG -> DS (in isoform SLCO1B3-2); 685..702; GTDSKTCNLDMQDNAAAN -> EEQ (in isoform SLCO1B3-2)
3D Structural Models
Turn
425..427; 437..439
Helix
27..50; 52..59; 63..84; 93..112; 114..117; 171..185; 188..199; 208..216; 218..230; 258..273; 274..276; 325..334; 336..357; 359..367; 371..400; 404..424; 458..461; 484..487; 505..507; 528..560; 565..567; 568..584; 587..597; 618..648
Beta Strand
242..244; 444..447; 473..475; 480..482; 519..522; 599..602; 612..616
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Domain (CC)
A conserved histidine residue in the third TMD (His-115) may play an essential role in the pH sensitivity of SLCO1B3/OATP1B3-mediated substrate transport.
Domain (FT)
453..508; Kazal-like
Protein Families
Organo anion transporter (TC 2.A.60) family
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Clinical Relevance
Drugs
CARBOPLATINSUNITINIBPRAVASTATIN SODIUM[3H]BSPGLYCYRRHIZIC ACIDISOSILYBIN BMYCOPHENOLATE[3H]ESTRADIOL-17&BETA-GLUCURONIDESILIBININSULFOBROMOPHTHALEINSILIDIANINELTROMBOPAGNULLWARFARINIRINOTECAN HYDROCHLORIDEPACLITAXELSILDENAFIL[3H]CCK-8 (HUMAN, MOUSE, RAT)TELMISARTANVORICONAZOLECYCLOSPORINEGEMFIBROZILMK-8245RIFAMPINDIOSCINRIFAMYCIN SV