Protein detail

GPC5C

G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3)

Entry name GPC5C	UniProt ID Q9NQ84	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3)

Protein Class (4)

G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (4)

G-protein coupled receptors:Family 3 (C) receptors
Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

51..71; Helical; Name=1; 86..106; Helical; Name=2; 121..141; Helical; Name=3; 156..176; Helical; Name=4; 209..229; Helical; Name=5; 242..262; Helical; Name=6; 280..300; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000170412

Entrez Gene Symbol

GPRC5C

Gene Synonym

RAIG-3

Gene Description

G protein-coupled receptor class C group 5 member C

Chromosome

Position

74424851-74451653

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificheart muscleCell SpecificColonocytesSingle-Nuclei Brain Specificendothelial cell

Function & Pathway5

Protein Function (4)

G-protein coupled receptors:Family 3 (C) receptors
Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (6)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence40

Ligand-Receptor Signaling (38)

38 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GOLPH3L GPRC5C	Q9H4A5 Q9NQ84	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27863537

Sequence, Structure & Domains8

Sequences

Length

441

Mass

48,193

Sequence

MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQ84-1; Sequence=Displayed; Name=2; IsoId=Q9NQ84-2; Sequence=VSP_037725

Alternative Sequence

1; M -> MGTQPEPGLGARM (in isoform 2)

Domain & Motif Annotations

Region

412..441; Disordered

Protein Families

G-protein coupled receptor 3 family

Sequence Similarities

Belongs to the G-protein coupled receptor 3 family.

Clinical Relevance4

Antibody

HPA029776

Interaction Protein

ENSG00000103769

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available