Protein detail

GPC5C

G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3)

Entry name GPC5C	UniProt ID Q9NQ84	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3)

Protein Class (4)

G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (4)

G-protein coupled receptors:Family 3 (C) receptors
Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

51..71; Helical; Name=1; 86..106; Helical; Name=2; 121..141; Helical; Name=3; 156..176; Helical; Name=4; 209..229; Helical; Name=5; 242..262; Helical; Name=6; 280..300; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000170412

Entrez Gene Symbol

GPRC5C

Gene Synonym

RAIG-3

Gene Description

G protein-coupled receptor class C group 5 member C

Chromosome

Position

74424851-74451653

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificheart muscleCell SpecificColonocytesSingle-Nuclei Brain Specificendothelial cell

Function & Pathway5

Protein Function (4)

G-protein coupled receptors:Family 3 (C) receptors
Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (6)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence40

Ligand-Receptor Signaling (38)

38 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
gpcr	receptor	GPCRdb	No	Yes	No	Yes	No
gpcr_orphan	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GOLPH3L GPRC5C	Q9H4A5 Q9NQ84	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27863537

Sequence, Structure & Domains8

Sequences

Length

441

Mass

48,193

Sequence

MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQ84-1; Sequence=Displayed; Name=2; IsoId=Q9NQ84-2; Sequence=VSP_037725

Alternative Sequence

1; M -> MGTQPEPGLGARM (in isoform 2)

Domain & Motif Annotations

Region

412..441; Disordered

Protein Families

G-protein coupled receptor 3 family

Sequence Similarities

Belongs to the G-protein coupled receptor 3 family.

Clinical Relevance4

Antibody

HPA029776

Interaction Protein

ENSG00000103769

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available