Protein detail
DDX4
Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog)
Entry name DDX4 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog)
Protein Class (2)
EnzymesPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
VASA
Gene Description
DEAD-box helicase 4
Chromosome
5
Position
55738017-55817157
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Function & Pathway7
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Reactome (5)
Canonical Pathways (3)
- M169 Pid integrin2 pathway
- M159 Pid amb2 neutrophils pathway
- M53 Pid integrin3 pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence64
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (59)
59 records.
Sequence, Structure & Domains11
Sequences
Length
724
Mass
79,308
Sequence
MGDEDWEAEINPHMSSYVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDAGECNKRDNTSTMGGFGVGKSFGNRGFSNSRFEDGDSSGFWRESSNDCEDNPTRNRGFSKRGGYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPNNDLDPDECMQRTGGLFGSRRPVLSGTGNGDTSQSRSGSGSERGGYKGLNEEVITGSGKNSWKSEAEGGESSDTQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGSTRGNVFASVDTRKGKSTLNTAGFSSSQAPNPVDDESWD
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NQI0-1; Sequence=Displayed; Name=2; IsoId=Q9NQI0-2; Sequence=VSP_011197; Name=3; IsoId=Q9NQI0-3; Sequence=VSP_046132, VSP_011197, VSP_046133; Name=4; IsoId=Q9NQI0-4; Sequence=VSP_047177
Alternative Sequence
1..111; MGDEDWEAEINPHMSSYVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDAGECNKRDNTSTMGGFGVGKSFGNRGFSNSRFEDGDSSGFWR -> MGSRNLFLTNSP (in isoform 3); 112..131; Missing (in isoform 4); 132..166; GYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPN -> D (in isoform 2 and isoform 3); 209..225; GGYKGLNEEVITGSGKN -> D (in isoform 3)
Domain & Motif Annotations
Compositional Bias
30..42; Polar residues; 69..78; Basic and acidic residues; 150..162; Gly residues; 195..205; Low complexity; 704..715; Polar residues
Motif
288..316; Q motif; 446..449; DEAD box
Domain (FT)
319..502; Helicase ATP-binding; 530..675; Helicase C-terminal
Region
1..246; Disordered; 228..247; Interaction with RANBP9; 704..724; Disordered
Protein Families (2)
- DEAD box helicase family
- DDX4/VASA subfamily
Sequence Similarities
Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37387557 | Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy. | No abstract available |