Protein detail

DDX4

Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog)

Entry name
DDX4
UniProt ID
Q9NQI0
EVMP score
0.38
Frequency
1
Transmembrane count
Protein classification
EnzymesPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog)
Protein Class
EnzymesPredicted intracellular proteins
Protein Function
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Ensembl
ENSG00000152670
Entrez Gene Symbol
DDX4
Gene Synonym
VASA
Gene Description
DEAD-box helicase 4
Chromosome
5
Position
55738017-55817157
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
  • M169 Pid integrin2 pathway
  • M159 Pid amb2 neutrophils pathway
  • M53 Pid integrin3 pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

59 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CDC5LDDX42DHX35U2AF1U2AF2P26368Q01081Q86XP3Q99459Q9H5Z11:1:1:1:1NetworkBlastCompleatCompleat:HC7328
DDX42RBM10P98175Q86XP30:0hu.MAP2
DDX46SHCBP1SRSF11ZNF592Q05519Q7L014Q8NEM2Q926100:0:0:0Havugimana2012Havugimana2012:C_176
DDX49NSUN5PWP2TBL3WDR3Q12788Q15269Q96P11Q9UNX4Q9Y6V70:0:0:0:0hu.MAP
DDX43IKSMU1Q13123Q2TAY7Q9NXZ20:0:0hu.MAP
AGO1AGO2DDX47SART3Q15020Q9H0S4Q9UKV8Q9UL181:1:1:1CompleatCFinderCompleat:HC6060
DDX47EXOSC4EXOSC7EXOSC8Q15024Q96B26Q9H0S4Q9NPD30:0:0:0Havugimana2012Havugimana2012:C_313
DDX43SMU1UHRF2Q2TAY7Q96PU4Q9NXZ20:0:0hu.MAP
DDX43SMU1Q2TAY7Q9NXZ20:0hu.MAP
CLVS2DDX41PITRM1Q5JRX3Q5SYC1Q9UJV90:0:0hu.MAP
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Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryR Sequencing435119778278218493871651239223661
Sequence, Structure & Domains

Sequences

Length
724
Mass
79,308
Sequence
MGDEDWEAEINPHMSSYVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDAGECNKRDNTSTMGGFGVGKSFGNRGFSNSRFEDGDSSGFWRESSNDCEDNPTRNRGFSKRGGYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPNNDLDPDECMQRTGGLFGSRRPVLSGTGNGDTSQSRSGSGSERGGYKGLNEEVITGSGKNSWKSEAEGGESSDTQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGSTRGNVFASVDTRKGKSTLNTAGFSSSQAPNPVDDESWD
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NQI0-1; Sequence=Displayed; Name=2; IsoId=Q9NQI0-2; Sequence=VSP_011197; Name=3; IsoId=Q9NQI0-3; Sequence=VSP_046132, VSP_011197, VSP_046133; Name=4; IsoId=Q9NQI0-4; Sequence=VSP_047177
Alternative Sequence
1..111; MGDEDWEAEINPHMSSYVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDAGECNKRDNTSTMGGFGVGKSFGNRGFSNSRFEDGDSSGFWR -> MGSRNLFLTNSP (in isoform 3); 112..131; Missing (in isoform 4); 132..166; GYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPN -> D (in isoform 2 and isoform 3); 209..225; GGYKGLNEEVITGSGKN -> D (in isoform 3)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
30..42; Polar residues; 69..78; Basic and acidic residues; 150..162; Gly residues; 195..205; Low complexity; 704..715; Polar residues
Motif
288..316; Q motif; 446..449; DEAD box
Domain (FT)
319..502; Helicase ATP-binding; 530..675; Helicase C-terminal
Region
1..246; Disordered; 228..247; Interaction with RANBP9; 704..724; Disordered
Protein Families
  • DEAD box helicase family
  • DDX4/VASA subfamily
Sequence Similarities
Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
Clinical Relevance
Antibody
CAB026170HPA037763HPA037764